Detailed information of TA system TA183782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 455217..455729
• Replicon: chromosome
• Accession: NZ_CP066021
• Organism: Streptococcus oralis strain FDAARGOS_1020

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: D4FRF2
• Locus tag: I6H77_RS02240
• Protein ID: WP_000924723.1
• Coordinates: 455217..455471 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: I6H77_RS02245
• Protein ID: WP_004181012.1
• Coordinates: 455475..455729 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H77_RS02225	452300..452614	-	315	WP_002874282.1	DNA-directed RNA polymerase subunit omega	-
I6H77_RS02230	452639..453265	-	627	WP_000775041.1	guanylate kinase	-
I6H77_RS02235	453400..455013	-	1614	WP_000404956.1	ribonuclease Y	-
I6H77_RS02240	455217..455471	-	255	WP_000924723.1	Txe/YoeB family addiction module toxin	Toxin
I6H77_RS02245	455475..455729	-	255	WP_004181012.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6H77_RS02250	455862..456959	-	1098	WP_000156374.1	nucleotidyltransferase	-
I6H77_RS02255	456969..457715	-	747	WP_078232917.1	class I SAM-dependent methyltransferase	-
I6H77_RS02260	458030..458383	-	354	WP_001003013.1	ribosome silencing factor	-
I6H77_RS02265	458384..458977	-	594	WP_000331233.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
I6H77_RS02270	458977..459606	-	630	WP_000963719.1	nicotinate-nucleotide adenylyltransferase	-
I6H77_RS02275	459657..459968	-	312	WP_000060169.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10113.58 Da
• Isoelectric Point: 7.9716

>T183782 WP_000924723.1 NZ_CP066021:c455471-455217 [Streptococcus oralis]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFVGMGKPEPLKYDYQGAWSRRIDAENRLIYMIDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T183782 NZ_CP087181:4389131-4389433 [Pseudomonas sp. B21-031]
ATGAAGAAGATCGAATCCAGCAGTTTCAGACATTGGGTGCATGGGCTCCGGGACGAAATGGCGCGTATCCGGATCATTGC
TCGTATTAACCGTTTGATGGAGGGCCTGTCTGGTGACGTCTCAGCAGTTGGCCACGGCGTGAGTGAACTCCGAATTCACC
ATGGTCCGGGCTACCGGGTGTACTTTCACCAAGCAGGCGATACGTTGGTAATACTGCTTTGCGGCGGGGACAAGAGCAGC
CAGCGGCGGGACATCAAAGCGGCTCACGAAATCCTGCGTTCCTGGAGGATGCAAAATGACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9734.05 Da
• Isoelectric Point: 4.8430

>AT183782 WP_004181012.1 NZ_CP066021:c455729-455475 [Streptococcus oralis]
MEVVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Nucleotide

• Length: 255 bp

>AT183782 NZ_CP087181:4389426-4389719 [Pseudomonas sp. B21-031]
ATGACTGAAACATTTTTTGAGTTCGATGCGGCCGATTACCTGACCACTCCGCAAGCCATCGCTCAATTCATGTCCGATGC
GCTGGAAACGGGTGATGCCAGCTACGTGGCCAAAGCCGTTGGCGTAGTGGCTCGTGCAAAAGGGATGAGCGATCTGGCGA
AAGAAACCGGCTTGTCTCGTGAGCAACTTTACCGATCGTTCAGCGAACACGGCAATCCGACCCTTAAATCGTTCCTCGCA
GTCATGAAGGCGTTGGGCATAGACATGACGGCAAAACCTCACCTTGCACACTAA

Structures

Toxin

• AlphaFold DB: A0A1X0WZT2