Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1280845..1281580 Replicon chromosome
Accession NZ_CP066018
Organism Cupriavidus necator strain FDAARGOS_1030

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7T4FXN9
Locus tag I6H87_RS05950 Protein ID WP_041687119.1
Coordinates 1281278..1281580 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID R7XDR2
Locus tag I6H87_RS05945 Protein ID WP_010813310.1
Coordinates 1280845..1281246 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H87_RS05920 1276111..1276977 + 867 WP_011614412.1 diaminopimelate epimerase -
I6H87_RS05925 1277085..1277894 + 810 WP_011614411.1 polyphosphate kinase 2 family protein -
I6H87_RS05930 1277909..1279183 - 1275 WP_010813313.1 patatin-like phospholipase family protein -
I6H87_RS05935 1279345..1280031 - 687 WP_010813312.1 orotate phosphoribosyltransferase -
I6H87_RS05940 1280059..1280835 + 777 WP_011614408.1 exodeoxyribonuclease III -
I6H87_RS05945 1280845..1281246 - 402 WP_010813310.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
I6H87_RS05950 1281278..1281580 - 303 WP_041687119.1 type II toxin-antitoxin system MqsR family toxin Toxin
I6H87_RS05955 1281759..1282706 + 948 WP_010813308.1 N-acetyl-gamma-glutamyl-phosphate reductase -
I6H87_RS05960 1282777..1283739 - 963 WP_010813307.1 M48 family metallopeptidase -
I6H87_RS05965 1283890..1285149 + 1260 WP_010813306.1 muropeptide transporter -
I6H87_RS05970 1285163..1286011 - 849 WP_011614406.1 thioesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(7-98)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11199.02 Da        Isoelectric Point: 8.7037

>T183773 WP_041687119.1 NZ_CP066018:c1281580-1281278 [Cupriavidus necator]
ICAGKGTAHDPLWRVRELIAAGRVSLTMAAFQGARNMCLTRGDVLDVVARIQPADFYKSMTTYVDHTVWQDVYRPCTSYG
AIYLKLTVTEEVLIVSFKAR

Download         Length: 303 bp

>T183773 NZ_CP087177:5201501-5201779 [Pseudomonas moraviensis]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGTGGCTTCTATGAAACAGGTACGACTCGTGGAATTCGTGCTGACCATGC
AAAACGGCTGTCGCGCATGTTGCAGTTCATGGATCGAGCGACGCTTCCCGGGGACTTGGACTTGCCCGGCTGGCGCCTGC
ATCCTTTGAAAGGTGAGCTAAGCGAATATTGGTCGCTCAGCGTTTCAGACAACTGGCGAGTGATCTTTCGTTTTGTCGGT
TCGGATATCGAATTGGTCGATTATCTGGACTACCACTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14845.05 Da        Isoelectric Point: 5.8009

>AT183773 WP_010813310.1 NZ_CP066018:c1281246-1280845 [Cupriavidus necator]
MRCPVCGGAELERGRKDFVYTYRGESTVIEAVLADWCAQCGEGVLGQEEEERIGPLALAFNKQVNASLVDPTYIMQVRKK
LHLDQREAAEIFGGGVNAFSRYETGRTKPPLALVKLLRLLDRHPELLEEVRAA

Download         Length: 402 bp

>AT183773 NZ_CP087177:5201794-5202081 [Pseudomonas moraviensis]
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACCCTGCTGCTGGATGTCTTGCCCGAGCTTGGCATCAGCGTGAGCGA
ATTAGCCCGGCACCTTGGCTTTGCACGCCCGCACCTTTCGCGCGTACTGCACGGACACGCGCCAATCAGCCCGGATCTGG
CAGTACGACTTGAACGTGCAGGGATTGGCAAGGCGCGCGTGTGGCTAGGTGTTCAAACCGACTACGATCTTTGGCAAGCG
GAGCACCGTGAGCAACCAATGATAGAACCCCTCGCAGCCCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4FXN9

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4FWF9

References