Detailed information of TA system TA183769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2491703..2492219
• Replicon: chromosome
• Accession: NZ_CP066015
• Organism: Kytococcus sedentarius strain FDAARGOS_1061

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: C7NJ00
• Locus tag: I6I18_RS11875
• Protein ID: WP_012801644.1
• Coordinates: 2491703..2491960 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C7NJ01
• Locus tag: I6I18_RS11880
• Protein ID: WP_012801645.1
• Coordinates: 2491962..2492219 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I18_RS11850	2486900..2488645	+	1746	WP_012801639.1	ABC transporter ATP-binding protein/permease	-
I6I18_RS11855	2488688..2489002	+	315	WP_012801640.1	MerR family transcriptional regulator	-
I6I18_RS11860	2489058..2490035	+	978	WP_143827315.1	GNAT family N-acetyltransferase	-
I6I18_RS11865	2490264..2491229	-	966	WP_012801642.1	winged helix-turn-helix domain-containing protein	-
I6I18_RS11870	2491276..2491689	+	414	WP_041291019.1	glyoxalase	-
I6I18_RS11875	2491703..2491960	-	258	WP_012801644.1	Txe/YoeB family addiction module toxin	Toxin
I6I18_RS11880	2491962..2492219	-	258	WP_012801645.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6I18_RS11885	2492329..2492865	+	537	WP_012801646.1	GNAT family N-acetyltransferase	-
I6I18_RS11890	2492869..2493258	+	390	WP_012801647.1	VOC family protein	-
I6I18_RS11895	2493436..2494572	+	1137	WP_012801648.1	FAD-dependent oxidoreductase	-
I6I18_RS11900	2494636..2495133	+	498	WP_041290814.1	tetratricopeptide repeat protein	-
I6I18_RS11905	2495171..2496148	-	978	WP_012801650.1	DUF2332 domain-containing protein	-
I6I18_RS11910	2496153..2496854	-	702	WP_012801651.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2479650..2495133	15483

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10146.45 Da
• Isoelectric Point: 8.9192

>T183769 WP_012801644.1 NZ_CP066015:c2491960-2491703 [Kytococcus sedentarius]
VRLVWDENAWEDYLWWQAQDRKVLKRINTLLKDVARNGNEGTGKPEALKHSLAGYWSRRITDEHRLVHKVTEDEIRIAAC
RYHYG

Nucleotide

• Length: 258 bp

>T183769 NZ_CP087177:2736010-2736294 [Pseudomonas moraviensis]
TTGAGGACCTATGAGCTGGAGTTTTCTGATAAGGCTTGGAGAGAGTGGGGGAAACTCGGGTCGGAACTCAGGCAGCAGTT
CAAAAACAAACTTTTGGAGAGGCTGGCAAATCCGCACGTTCCGGCGGCTCGCCTGAAAGGGTTGAGTAACGCCTATAAAA
TCAAGCTTCGAAGCGCTGGATATCGGTTGGTCTATCGGGTAAGGGATGAGGTGCTGGTCGTTACGGTGATAGCGGTCGGG
AAACGGCAGGGTGGTGACGTTTACAAGCAGGCTCTCAAACGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9729.83 Da
• Isoelectric Point: 4.4985

>AT183769 WP_012801645.1 NZ_CP066015:c2492219-2491962 [Kytococcus sedentarius]
VKTLSYTESRRRYAEVLDHVVDDREEVVITRAGHEPVVIVSLEEYESLRETAYLMRSPANARRLLDAMDRLEAGGGTEHE
LIETD

Nucleotide

• Length: 258 bp

>AT183769 NZ_CP087177:2735775-2736023 [Pseudomonas moraviensis]
ATGACGCACATCGTTCTTTCTCATGTCGTAGCGAGTATTTCCGAATTGAAAAAAAATCCTATGGGTACAGTCGCTGCTGG
TGGAGGCCGGTCAGTGGCGATCCTTAATCGAAACGAACCGGCTTTTTATTGCGTGCCCGCCAAAGAATACGAGGCAATGA
TGGAGCGCCTTGATGATCTGGAACTGATCGCCCTCTGTAGGGAGCGAGAAAACGATCCGACCATCAAGGTATCCATTGAG
GACCTATGA

Structures

Toxin

• AlphaFold DB: C7NJ00

Antitoxin

• AlphaFold DB: C7NJ01