Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2491703..2492219 Replicon chromosome
Accession NZ_CP066015
Organism Kytococcus sedentarius strain FDAARGOS_1061

Toxin (Protein)


Gene name yoeB Uniprot ID C7NJ00
Locus tag I6I18_RS11875 Protein ID WP_012801644.1
Coordinates 2491703..2491960 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C7NJ01
Locus tag I6I18_RS11880 Protein ID WP_012801645.1
Coordinates 2491962..2492219 (-) Length 86 a.a.

Genomic Context

I6I18_RS11850I6I18_RS11855I6I18_RS11860I6I18_RS11870I6I18_RS11885I6I18_RS11890I6I18_RS11895I6I18_RS11900I6I18_RS11865I6I18_RS11875I6I18_RS11880I6I18_RS11905I6I18_RS11910
Location: 2486900..2488645 (1746 bp)
Type: Others
Protein ID: WP_012801639.1
Location: 2488688..2489002 (315 bp)
Type: Others
Protein ID: WP_012801640.1
Location: 2489058..2490035 (978 bp)
Type: Others
Protein ID: WP_143827315.1
Location: 2491276..2491689 (414 bp)
Type: Others
Protein ID: WP_041291019.1
Location: 2492329..2492865 (537 bp)
Type: Others
Protein ID: WP_012801646.1
Location: 2492869..2493258 (390 bp)
Type: Others
Protein ID: WP_012801647.1
Location: 2493436..2494572 (1137 bp)
Type: Others
Protein ID: WP_012801648.1
Location: 2494636..2495133 (498 bp)
Type: Others
Protein ID: WP_041290814.1
Location: 2490264..2491229 (966 bp)
Type: Others
Protein ID: WP_012801642.1
Location: 2491703..2491960 (258 bp)
Type: Toxin
Protein ID: WP_012801644.1
Location: 2491962..2492219 (258 bp)
Type: Antitoxin
Protein ID: WP_012801645.1
Location: 2495171..2496148 (978 bp)
Type: Others
Protein ID: WP_012801650.1
Location: 2496153..2496854 (702 bp)
Type: Others
Protein ID: WP_012801651.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I18_RS118502486900..2488645+1746WP_012801639.1ABC transporter ATP-binding protein/permease-
I6I18_RS118552488688..2489002+315WP_012801640.1MerR family transcriptional regulator-
I6I18_RS118602489058..2490035+978WP_143827315.1GNAT family N-acetyltransferase-
I6I18_RS118652490264..2491229-966WP_012801642.1winged helix-turn-helix domain-containing protein-
I6I18_RS118702491276..2491689+414WP_041291019.1glyoxalase-
I6I18_RS118752491703..2491960-258WP_012801644.1Txe/YoeB family addiction module toxinToxin
I6I18_RS118802491962..2492219-258WP_012801645.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
I6I18_RS118852492329..2492865+537WP_012801646.1GNAT family N-acetyltransferase-
I6I18_RS118902492869..2493258+390WP_012801647.1VOC family protein-
I6I18_RS118952493436..2494572+1137WP_012801648.1FAD-dependent oxidoreductase-
I6I18_RS119002494636..2495133+498WP_041290814.1tetratricopeptide repeat protein-
I6I18_RS119052495171..2496148-978WP_012801650.1DUF2332 domain-containing protein-
I6I18_RS119102496153..2496854-702WP_012801651.1class I SAM-dependent methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2479650..249513315483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10146.45 Da        Isoelectric Point: 8.9192

>T183769 WP_012801644.1 NZ_CP066015:c2491960-2491703 [Kytococcus sedentarius]
VRLVWDENAWEDYLWWQAQDRKVLKRINTLLKDVARNGNEGTGKPEALKHSLAGYWSRRITDEHRLVHKVTEDEIRIAAC
RYHYG

Download         Length: 258 bp

>T183769 NZ_CP087177:2736010-2736294 [Pseudomonas moraviensis]
TTGAGGACCTATGAGCTGGAGTTTTCTGATAAGGCTTGGAGAGAGTGGGGGAAACTCGGGTCGGAACTCAGGCAGCAGTT
CAAAAACAAACTTTTGGAGAGGCTGGCAAATCCGCACGTTCCGGCGGCTCGCCTGAAAGGGTTGAGTAACGCCTATAAAA
TCAAGCTTCGAAGCGCTGGATATCGGTTGGTCTATCGGGTAAGGGATGAGGTGCTGGTCGTTACGGTGATAGCGGTCGGG
AAACGGCAGGGTGGTGACGTTTACAAGCAGGCTCTCAAACGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9729.83 Da        Isoelectric Point: 4.4985

>AT183769 WP_012801645.1 NZ_CP066015:c2492219-2491962 [Kytococcus sedentarius]
VKTLSYTESRRRYAEVLDHVVDDREEVVITRAGHEPVVIVSLEEYESLRETAYLMRSPANARRLLDAMDRLEAGGGTEHE
LIETD

Download         Length: 258 bp

>AT183769 NZ_CP087177:2735775-2736023 [Pseudomonas moraviensis]
ATGACGCACATCGTTCTTTCTCATGTCGTAGCGAGTATTTCCGAATTGAAAAAAAATCCTATGGGTACAGTCGCTGCTGG
TGGAGGCCGGTCAGTGGCGATCCTTAATCGAAACGAACCGGCTTTTTATTGCGTGCCCGCCAAAGAATACGAGGCAATGA
TGGAGCGCCTTGATGATCTGGAACTGATCGCCCTCTGTAGGGAGCGAGAAAACGATCCGACCATCAAGGTATCCATTGAG
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC7NJ00

Antitoxin

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Source
ID
Structure
AlphaFold DBC7NJ01

References