Detailed information of TA system TA183764

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1387653..1388023
• Replicon: chromosome
• Accession: NZ_CP066013
• Organism: Staphylococcus equorum strain FDAARGOS_1068

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A1E5TGW5
• Locus tag: I6I25_RS06995
• Protein ID: WP_021338679.1
• Coordinates: 1387653..1387874 (-)
• Length: 74 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1387925..1388023 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I25_RS06970	1383024..1383581	+	558	WP_021338684.1	GNAT family N-acetyltransferase	-
I6I25_RS06975	1383643..1385526	-	1884	WP_069812506.1	glycosyltransferase family 2 protein	-
I6I25_RS06980	1385833..1386603	-	771	WP_021338682.1	hypothetical protein	-
I6I25_RS06985	1386976..1387083	-	108	WP_021338681.1	putative holin-like toxin	-
I6I25_RS06990	1387382..1387498	-	117	WP_165349553.1	putative holin-like toxin	-
I6I25_RS06995	1387653..1387874	-	222	WP_021338679.1	phage holin	Toxin
-	1387925..1388023	+	99	-	-	Antitoxin
I6I25_RS07000	1388664..1389152	+	489	WP_081324772.1	ATP-binding protein	-
I6I25_RS07005	1389180..1389587	-	408	WP_198456268.1	YolD-like family protein	-
I6I25_RS07010	1389717..1390406	+	690	WP_198456269.1	hypothetical protein	-
I6I25_RS07015	1390495..1390644	-	150	WP_198456270.1	hypothetical protein	-
I6I25_RS07020	1390796..1391041	+	246	Protein_1310	transcriptional regulator	-
I6I25_RS07025	1391159..1391689	+	531	WP_075339968.1	Bsp6I family type II restriction endonuclease	-
I6I25_RS07030	1391751..1392719	+	969	WP_198456271.1	DNA cytosine methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1383643..1394690	11047

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (7-59)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8279.78 Da
• Isoelectric Point: 4.8018

>T183764 WP_021338679.1 NZ_CP066013:c1387874-1387653 [Staphylococcus equorum]
MDVKVTVIVRVLSLILVLVNQWLSNKEVSPIPVDESTLMTIAVALITMWKDNPFTDAAKGSFFKSYTYQLEIF

Nucleotide

• Length: 222 bp

>T183764 NZ_CP087177:182385-182666 [Pseudomonas moraviensis]
ATGACTTATAAGCTTGAGTTTCTGCCGTCTGCGCACAAAGAGTGGAACAAGCTGGGTCATACGTTGCGGGAGCAGTTCAA
AAAGAAGCTGGGTGAGAGGCTGAAGCTTCCCAGAATCCCGGCTGACGCCCTCCACAGCATGCCCGACTGCTACAAAATCA
AACTCAAAGCCTCGGGATATCGATTGGTTTACCAAGTCATCGACGAACGAGTCGTGGTTTCCGTGCTAGCGGTTGGCAAG
CGCGAACGCAGCAGCGTTTACGATGCTGCCAAGAACCGTTGA

Antitoxin

Nucleotide

• Length: 99 bp

>AT183764 NZ_CP066013:1387925-1388023 [Staphylococcus equorum]
ATTTGATAATATTTATATGTTGTGTTAATTTATATATAGAAAAAGGGCAACACACCATACGTGTATCGCCCCAATGAGCC
CGTTAAAAAGACGGTGGCT

Structures

Toxin

• AlphaFold DB: A0A1E5TGW5

Antitoxin