Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6008982..6009605 Replicon chromosome
Accession NZ_CP066006
Organism Delftia acidovorans strain FDAARGOS_997

Toxin (Protein)


Gene name higB Uniprot ID A0A7T4EMD5
Locus tag I6H54_RS27400 Protein ID WP_034397745.1
Coordinates 6009324..6009605 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6H54_RS27395 Protein ID WP_034399070.1
Coordinates 6008982..6009281 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H54_RS27370 6004771..6005706 + 936 WP_034397750.1 LysR family transcriptional regulator -
I6H54_RS27375 6005967..6006740 + 774 WP_012202207.1 ferredoxin--NADP reductase -
I6H54_RS27380 6006785..6007591 + 807 WP_012202206.1 IclR family transcriptional regulator -
I6H54_RS27385 6007725..6008498 + 774 WP_034397748.1 SDR family oxidoreductase -
I6H54_RS27390 6008648..6008956 + 309 WP_080737020.1 BrnA antitoxin family protein -
I6H54_RS27395 6008982..6009281 - 300 WP_034399070.1 HigA family addiction module antidote protein Antitoxin
I6H54_RS27400 6009324..6009605 - 282 WP_034397745.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H54_RS27405 6009735..6010910 - 1176 WP_013800139.1 ABC transporter substrate-binding protein -
I6H54_RS27410 6011088..6011795 - 708 WP_034399068.1 ABC transporter ATP-binding protein -
I6H54_RS27415 6011782..6012546 - 765 WP_034397744.1 ABC transporter ATP-binding protein -
I6H54_RS27420 6012533..6013507 - 975 WP_016448673.1 branched-chain amino acid ABC transporter permease -
I6H54_RS27425 6013508..6014371 - 864 WP_012202199.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.66 Da        Isoelectric Point: 9.3564

>T183753 WP_034397745.1 NZ_CP066006:c6009605-6009324 [Delftia acidovorans]
MTIQSFKCPDTEQLFQQRRVRRWSGIEVVALRKLRMLHAAHVLQDLRVPPGNRLEALQGDRKGQHSIRINDQWRVCFVWT
HEGPSELEIVDYH

Download         Length: 282 bp

>T183753 NZ_CP087175:c709495-709205 [Pseudomonas sp. B21-041]
ATGAGCGAAGAATTCGCCCGTTTTGACGCCGCCGAGTACCTCAAAACTCCCGAGGACATGGCGGCGTATCTGGATGCCTG
TTTTGACGACGATGAAGGCGACGGCGTCCTTATCCGTGCAGCGCTCAATGACATCGCCCGGGCTCAAGGCATGACACAAG
TGGCGCGGGATGCAGGTTTGGGCCGCGAAAGTCTTTATAAAGCGCTGAGTAGCACTGGCAATCCCGAATTCGCAACTATC
ATGAAAGTCATGAAGGCTCTGGGTTTGCGATTGCATGCCGTAACACTGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11023.66 Da        Isoelectric Point: 5.0190

>AT183753 WP_034399070.1 NZ_CP066006:c6009281-6008982 [Delftia acidovorans]
MNKPLNLPTPGEILATEFLEPMGLTQYRLAQAIHVPQTRIAAIVKNGRSITADTALRLARFFGTSVEFWMNLQSQYDADM
ARKSIGDDLESIEPFALQA

Download         Length: 300 bp

>AT183753 NZ_CP087175:c709801-709499 [Pseudomonas sp. B21-041]
ATGATCGCTTTTGAACGATCCCGCATATTTTCCGAATGGCTCGACTCCTTGAAAGACATCAAAGGGAAAGGCCGAATCAT
CTCCAGAATTAAAACAGCCGAAAATGGCAACTTCGGTGATTGCGGGTTCGTCGGTGACACTGTTTATGAAATGCGTGTTC
ATTACGGCCCTGGTTACAGGATGTACTTCACACGCAAAGGCGAAGTGATTTATCTGCTGCTGATCGGGGGCGACAAATCG
ACACAAAAAAGAGATATCAAACGCGCCGTGCAGATGGCTCATAACATCGGAAATGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References