Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 1686519..1687224 | Replicon | chromosome |
| Accession | NZ_CP065999 | ||
| Organism | Kingella denitrificans strain FDAARGOS_1060 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | F0EYC9 |
| Locus tag | I6I17_RS08535 | Protein ID | WP_003782192.1 |
| Coordinates | 1686519..1686818 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | F0EYD0 |
| Locus tag | I6I17_RS08540 | Protein ID | WP_003782194.1 |
| Coordinates | 1686820..1687224 (+) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6I17_RS08510 | 1681949..1682692 | + | 744 | WP_040564238.1 | phage Gp37/Gp68 family protein | - |
| I6I17_RS08515 | 1682731..1684011 | + | 1281 | WP_040564239.1 | three-Cys-motif partner protein TcmP | - |
| I6I17_RS08520 | 1684591..1685403 | - | 813 | WP_003782186.1 | hypothetical protein | - |
| I6I17_RS08525 | 1685415..1685636 | - | 222 | WP_003782188.1 | hypothetical protein | - |
| I6I17_RS08530 | 1685779..1686399 | + | 621 | WP_115324820.1 | helix-turn-helix domain-containing protein | - |
| I6I17_RS08535 | 1686519..1686818 | + | 300 | WP_003782192.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| I6I17_RS08540 | 1686820..1687224 | + | 405 | WP_003782194.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| I6I17_RS08545 | 1687350..1687718 | + | 369 | WP_003782197.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6I17_RS08550 | 1687715..1688029 | + | 315 | WP_003782198.1 | DNA-binding transcriptional regulator | - |
| I6I17_RS08555 | 1688094..1688492 | - | 399 | WP_003782200.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| I6I17_RS08560 | 1688544..1688861 | - | 318 | WP_003782201.1 | HigA family addiction module antidote protein | - |
| I6I17_RS08565 | 1688874..1689155 | - | 282 | WP_003782203.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6I17_RS08570 | 1689869..1690327 | - | 459 | WP_003782207.1 | hypothetical protein | - |
| I6I17_RS08575 | 1690560..1690949 | + | 390 | WP_040564241.1 | hypothetical protein | - |
| I6I17_RS08580 | 1690946..1691635 | + | 690 | WP_003782210.1 | hypothetical protein | - |
| I6I17_RS08585 | 1691892..1692155 | + | 264 | WP_003782212.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11255.88 Da Isoelectric Point: 7.2749
>T183751 WP_003782192.1 NZ_CP065999:1686519-1686818 [Kingella denitrificans]
VEKRTPHCKLEIVKALIAEGRVAATFSARRTAQEAGIDYAAMVEIVNNLNRSDFYKSMTTHADHTVWQDVYRPNVEPYGG
LYIKLTVIDDVLIVSFKER
VEKRTPHCKLEIVKALIAEGRVAATFSARRTAQEAGIDYAAMVEIVNNLNRSDFYKSMTTHADHTVWQDVYRPNVEPYGG
LYIKLTVIDDVLIVSFKER
Download Length: 300 bp
>T183751 NZ_CP087174:984535-984828 [Pseudomonas donghuensis]
TTGAAATACAGTGTTTTGCAAACGCCCAGATTCACCTCTTGGTTGATTTCCGTACGCGACATGCGTGCAAGGGTGGCAAT
CGCACGGCGAATAGAGCGTGTAACGGCGGGAAATCTGGGAGATGTGAAGTCCGTCGGTGGTCAGGTCTGCGAGATGCGCA
TCGATGTGGGGGCGGGTTATCGGGTGTATTTCACGGCTCGGGACGGTGTAGTCATTGTTTTGTTGGCAGGTGGTGACAAG
TCATCGCAATCTGTTGATATCCAACTGGCCAGGAAGCTGGCCAAGGAAATTTGA
TTGAAATACAGTGTTTTGCAAACGCCCAGATTCACCTCTTGGTTGATTTCCGTACGCGACATGCGTGCAAGGGTGGCAAT
CGCACGGCGAATAGAGCGTGTAACGGCGGGAAATCTGGGAGATGTGAAGTCCGTCGGTGGTCAGGTCTGCGAGATGCGCA
TCGATGTGGGGGCGGGTTATCGGGTGTATTTCACGGCTCGGGACGGTGTAGTCATTGTTTTGTTGGCAGGTGGTGACAAG
TCATCGCAATCTGTTGATATCCAACTGGCCAGGAAGCTGGCCAAGGAAATTTGA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14677.73 Da Isoelectric Point: 6.6973
>AT183751 WP_003782194.1 NZ_CP065999:1686820-1687224 [Kingella denitrificans]
MKCPVCGAAELVHDVRDVPYTYKGQTTVLPHVEADYCDACGDHLTGPAEGKRTMDLMGAFIKQVNERQADPNFIRSVRAK
LNLTQREAGDLFGGGVNAFSRYESGKVEPPKSLSILFALLDENPALLQRIRQAG
MKCPVCGAAELVHDVRDVPYTYKGQTTVLPHVEADYCDACGDHLTGPAEGKRTMDLMGAFIKQVNERQADPNFIRSVRAK
LNLTQREAGDLFGGGVNAFSRYESGKVEPPKSLSILFALLDENPALLQRIRQAG
Download Length: 405 bp
>AT183751 NZ_CP087174:984830-985129 [Pseudomonas donghuensis]
ATGAGTTTGTCACTTACTACGTTTGATATGGCCGCGTTGCTCGATAGCGATGAGACAATCAGCGAGTACCTTTCTCAAGT
GCTGGCGGATGGTGATCATGACGAACTGATTCGCGCCCTCGGCTATATCGCCAAGGCTCGCGGCATGAGCCAGATCGCAA
CTGCCAGTGGATTGGGGCGCGAGAGCCTGTACAAGGCGTTGACCCCCGGTGCGAAGCCTCGTTTTGACACTGTACTGAAG
GTCATCCGGGCGCTAGGGATTGATCTTCTGGCCCACCCTCATGCTTCGTCGAGACTCTGA
ATGAGTTTGTCACTTACTACGTTTGATATGGCCGCGTTGCTCGATAGCGATGAGACAATCAGCGAGTACCTTTCTCAAGT
GCTGGCGGATGGTGATCATGACGAACTGATTCGCGCCCTCGGCTATATCGCCAAGGCTCGCGGCATGAGCCAGATCGCAA
CTGCCAGTGGATTGGGGCGCGAGAGCCTGTACAAGGCGTTGACCCCCGGTGCGAAGCCTCGTTTTGACACTGTACTGAAG
GTCATCCGGGCGCTAGGGATTGATCTTCTGGCCCACCCTCATGCTTCGTCGAGACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|