183750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2097147..2097670 Replicon chromosome
Accession NZ_CP065998
Organism Staphylococcus pseudintermedius strain FDAARGOS_1072

Toxin (Protein)


Gene name yoeB Uniprot ID A0A317Z6J3
Locus tag I6I29_RS10420 Protein ID WP_037542127.1
Coordinates 2097147..2097413 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2P5PI69
Locus tag I6I29_RS10425 Protein ID WP_015729747.1
Coordinates 2097413..2097670 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I29_RS10400 2092399..2092545 - 147 WP_157978016.1 hypothetical protein -
I6I29_RS10405 2094320..2094421 - 102 Protein_2019 KxYKxGKxW signal peptide domain-containing protein -
I6I29_RS10410 2095178..2096671 + 1494 WP_014612817.1 malate dehydrogenase (quinone) -
I6I29_RS10415 2096685..2096786 + 102 WP_019169745.1 DUF2648 domain-containing protein -
I6I29_RS10420 2097147..2097413 - 267 WP_037542127.1 Txe/YoeB family addiction module toxin Toxin
I6I29_RS10425 2097413..2097670 - 258 WP_015729747.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6I29_RS10430 2097865..2099769 - 1905 WP_037542126.1 triacylglycerol lipase -
I6I29_RS10435 2100029..2100523 + 495 WP_037542124.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10555.10 Da        Isoelectric Point: 10.1602

>T183750 WP_037542127.1 NZ_CP065998:c2097413-2097147 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Download         Length: 267 bp

>T183750 NZ_CP087173:956062-956361 [Pseudomonas donghuensis]
ATGAGTTTGTCACTTACTACGTTTGATATGGCCGCGTTGCTCGATAGCGATGAGACAATCAGCGAGTACCTTTCTCAAGT
GCTGGCGGATGGTGATCATGACGAACTGATTCGCGCCCTCGGCTATATCGCCAAGGCTCGCGGCATGAGCCAGATCGCAA
CTGCCAGTGGATTGGGGCGCGAGAGCCTGTACAAGGCGTTGACCCCCGGTGCGAAGCCTCGTTTTGACACTGTACTGAAG
GTCATCCGGGCGCTAGGGATTGATCTTCTGGCCCACCCTCATGCTTCGTCGAGACTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9836.85 Da        Isoelectric Point: 4.1100

>AT183750 WP_015729747.1 NZ_CP065998:c2097670-2097413 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT183750 NZ_CP087173:955767-956060 [Pseudomonas donghuensis]
TTGAAATACAGTGTTTTGCAAACGCCCAGACTCACCTCTTGGTTGATTTCCGTACGCGACATGCGTGCAAGGGTGGCAAT
CGCACGGCGAATAGAGCGTGTAACGGCGGGAAATCTGGGAGATGTGAAGTCCGTCGGTGGTCAGGTCTGCGAGATGCGCA
TCGATGTGGGGGCGGGTTATCGGGTGTATTTCACGGCTCGGGACGGTGTAGTCATTGTTTTGTTGGCAGGTGGTGACAAG
TCATCGCAATCTGTTGATATCCAACTGGCCAGGAAGCTGGCCAAGGAAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A317Z6J3

Antitoxin

Source ID Structure
AlphaFold DB A0A2P5PI69

References