Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2339617..2340187 Replicon chromosome
Accession NZ_CP065989
Organism Brevibacterium casei strain FDAARGOS_990

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6H47_RS10255 Protein ID WP_198498449.1
Coordinates 2339617..2339898 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6H47_RS10260 Protein ID WP_198498450.1
Coordinates 2339885..2340187 (+) Length 101 a.a.

Genomic Context

I6H47_RS10235I6H47_RS10250I6H47_RS10255I6H47_RS10260I6H47_RS10265I6H47_RS10270I6H47_RS10275I6H47_RS10240I6H47_RS10245I6H47_RS10280I6H47_RS10285
Location: 2335113..2335571 (459 bp)
Type: Others
Protein ID: WP_198498445.1
Location: 2338629..2339510 (882 bp)
Type: Others
Protein ID: WP_198498448.1
Location: 2339617..2339898 (282 bp)
Type: Toxin
Protein ID: WP_198498449.1
Location: 2339885..2340187 (303 bp)
Type: Antitoxin
Protein ID: WP_198498450.1
Location: 2340187..2340645 (459 bp)
Type: Others
Protein ID: WP_198498451.1
Location: 2341539..2341964 (426 bp)
Type: Others
Protein ID: WP_198498452.1
Location: 2342188..2343336 (1149 bp)
Type: Others
Protein ID: WP_198498453.1
Location: 2336170..2337213 (1044 bp)
Type: Others
Protein ID: WP_198498446.1
Location: 2337248..2338492 (1245 bp)
Type: Others
Protein ID: WP_198498447.1
Location: 2343362..2343631 (270 bp)
Type: Others
Protein ID: WP_198498454.1
Location: 2343765..2344181 (417 bp)
Type: Others
Protein ID: WP_198498455.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6H47_RS102352335113..2335571+459WP_198498445.1NUDIX domain-containing protein-
I6H47_RS102402336170..2337213-1044WP_198498446.1alcohol dehydrogenase catalytic domain-containing protein-
I6H47_RS102452337248..2338492-1245WP_198498447.1MFS transporter-
I6H47_RS102502338629..2339510+882WP_198498448.1helix-turn-helix transcriptional regulator-
I6H47_RS102552339617..2339898+282WP_198498449.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6H47_RS102602339885..2340187+303WP_198498450.1HigA family addiction module antidote proteinAntitoxin
I6H47_RS102652340187..2340645+459WP_198498451.1hypothetical protein-
I6H47_RS102702341539..2341964+426WP_198498452.1DUF1801 domain-containing protein-
I6H47_RS102752342188..2343336+1149WP_198498453.1hypothetical protein-
I6H47_RS102802343362..2343631-270WP_198498454.1DUF3263 domain-containing protein-
I6H47_RS102852343765..2344181-417WP_198498455.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2331272..234400412732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10922.44 Da        Isoelectric Point: 8.0756

>T183742 WP_198498449.1 NZ_CP065989:2339617-2339898 [Brevibacterium casei]
VIRPFGDKETERLWHRERVRSIDPRILRVALRKLRQLGSAEALEDLRVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T183742 NZ_CP087171:c872323-872072 [Pseudomonas atacamensis]
ATGTCAAAGACTGAAAAACTTCTCGCCAAGCTAATCAACGGGCACAGCGCATTCACTTGGTCCGAGCTTGTCACTCTGTT
AGGTCGTCTTGGTTACTCCCAACTGGAAGGATCCGGTAGCAGGATCAAATTCGACAATGGGGATCCGAACGCATTGATCA
ACCTGCACAAGCCCCATCCCGGAAATGAAATCAAAACATACGCAAGACGCCAGATTATCGAGCAACTGAAAAAAGGAGGC
CTGATTCAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11064.59 Da        Isoelectric Point: 4.8255

>AT183742 WP_198498450.1 NZ_CP065989:2339885-2340187 [Brevibacterium casei]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLARYFGTSAEFWINLQSHYEL
DRAEELAGEQIASITPLSVA

Download         Length: 303 bp

>AT183742 NZ_CP087171:c872075-871734 [Pseudomonas atacamensis]
ATGAGTTCCCAGCTGCACTACAAAGGCTATGTTGGCTCTATCGAGGCGAGCACGGAAGATAAGTGCCTGTTCGGAAAACT
CCTTTTCATCAGGGCGCTGGTTAATTATGAAGGACAAACGGTGGCTGAACTGGAAGCAGCCTTTCGCGAGGCGGTAGATG
ACTATTTACAAACCTGTGAGCAGCTCGGGCAGAAGCCTGAAATCCCATGCAAAGGATCGTTCAATGTTCGCATCGGTCAC
GATCTGCATTTAGCAGCGGCTCTGGCGGCAACCCGTCAAAATGTGTCGTTGAATGATCTGACACGTCAAGCACTGAACGA
ATACCTCCAACACCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References