Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 366232..366754 Replicon chromosome
Accession NZ_CP065981
Organism Macrococcus caseolyticus strain FDAARGOS_1005

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag I6H62_RS01880 Protein ID WP_101140594.1
Coordinates 366232..366504 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag I6H62_RS01885 Protein ID WP_101140593.1
Coordinates 366497..366754 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H62_RS01850 362235..362621 + 387 WP_165980817.1 sporulation protein -
I6H62_RS01855 362752..363201 - 450 WP_101140597.1 GNAT family N-acetyltransferase -
I6H62_RS01860 363284..364024 + 741 WP_133453519.1 hypothetical protein -
I6H62_RS01865 364034..364624 + 591 WP_133453518.1 phosphotransferase -
I6H62_RS01870 364956..365441 + 486 WP_133453517.1 NUDIX domain-containing protein -
I6H62_RS01875 365447..366214 + 768 WP_133453516.1 hypothetical protein -
I6H62_RS01880 366232..366504 - 273 WP_101140594.1 Txe/YoeB family addiction module toxin Toxin
I6H62_RS01885 366497..366754 - 258 WP_101140593.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6H62_RS01890 366885..368057 - 1173 WP_133453515.1 MFS transporter -
I6H62_RS01895 368576..369070 + 495 WP_157820952.1 cysteine hydrolase -
I6H62_RS01900 369478..371091 + 1614 WP_101140590.1 ABC-F type ribosomal protection protein -
I6H62_RS01905 371066..371515 + 450 WP_101140589.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10708.44 Da        Isoelectric Point: 9.7663

>T183739 WP_101140594.1 NZ_CP065981:c366504-366232 [Macrococcus caseolyticus]
MPKKKILFYSSGFEDYTYWQSNDKTVLKRINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T183739 NZ_CP087171:174025-174306 [Pseudomonas atacamensis]
ATGACTTATAAGCTTGAGTTTCTGCCGTCTGCGCACAAAGAGTGGAACAAGCTGGGTCATACGTTGCGGGAGCAGTTCAA
AAAGAAGCTGGGTGAGAGGCTGAAGCTTCCGAGAATCCCGGCTGACGCCCTCCACAGCATGCCCGACTGCTACAAAATCA
AACTCAAAGCCTCGGGATATCGATTGGTTTACCAAGTCATCGACGAACGAGTCGTGGTTTCCGTGCTAGCGGTTGGCAAG
CGCGAACGCAGCAGCGTTTACGATGCTGCCAGGAACCGTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.84 Da        Isoelectric Point: 4.0338

>AT183739 WP_101140593.1 NZ_CP065981:c366754-366497 [Macrococcus caseolyticus]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTYNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT183739 NZ_CP087171:173790-174035 [Pseudomonas atacamensis]
ATGCAAAGCGTTCTCGCCGATATGGCTGTCAGTGTCTCTGAACTGAAGAAAAATCCTACTGCCGTGTTGAACGGTGCACA
TGGGGGGGCCGTCGCTGTCCTCAACCACAATCGCGTCATGGGCTATATGGTGCCGGCCGAAGTTTATGAAGCAATGATGG
AGCGGCTTGATGATCTTGAGCTGGCTGACATTGTTCGTTCGCGCCTCCACGAAACGCCCATTTCGGTAAGCCTGGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References