Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1677625..1678318 Replicon chromosome
Accession NZ_CP065970
Organism Escherichia coli strain FDAARGOS_1058

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6I15_RS08675 Protein ID WP_000415584.1
Coordinates 1677625..1677921 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6I15_RS08680 Protein ID WP_000650107.1
Coordinates 1677923..1678318 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I15_RS08645 1673300..1673614 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
I6I15_RS08650 1673645..1674226 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
I6I15_RS08655 1674336..1675685 - 1350 WP_000673406.1 two-component system sensor histidine kinase QseC -
I6I15_RS08660 1675682..1676341 - 660 WP_001221491.1 two-component system response regulator QseB -
I6I15_RS08665 1676493..1676885 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6I15_RS08670 1676938..1677420 + 483 WP_000183494.1 transcriptional regulator -
I6I15_RS08675 1677625..1677921 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6I15_RS08680 1677923..1678318 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6I15_RS08685 1678451..1680058 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
I6I15_RS08690 1680196..1682454 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1665897..1678318 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T183708 WP_000415584.1 NZ_CP065970:1677625-1677921 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T183708 NZ_CP087166:478649-478936 [Pseudomonas sp. B21-051]
ATGACCGAACAATTCACTCGTTGGGACTCAGCCGAGTACCTCAAGACAGAAGAGGACATGGCCAATTATCTGGATGCCTG
CATGGAGGAGGCTGGAGATGATCCTGCCTTTATCGCCAAGGCACTGGGCACCATTGCGAGAGCGCGAGGCATGACCCAAG
TCGCACGTGACGCCGGGCTGTCTCGAGAAAGTCTCTACCGTGCACTGTCAGGTGAAGGAAATCCTGAGTTTGGAACGATT
CTGAAAGTGGTGAAGGCGTTGGGCTTGAAGTTACATGCCAGCACTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT183708 WP_000650107.1 NZ_CP065970:1677923-1678318 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT183708 NZ_CP087166:478347-478652 [Pseudomonas sp. B21-051]
ATGCCCGAGATCATTCGAAGTTCAACATTCTCCACCTGGCTTTTGAAGCTGGCTGACAACCGCGCCAGGTTGCGTATTCA
GGTGCGCATTGATCGTATGGCCGATGGGAATTTTGGTGATGTCAAAGCCGTCGGTGAGGGGCTCAGCGAAGTCAGAATTG
ACTATGGCCCCGGATATCGAGTCTATTTCATGCAACAAGGTCGGCAAGTGGTCATCCTCCTTTGTGGTGGAGACAAGAGC
AGCCAACCCCGAGATATCAAGCAAGCCAGGCTCATCGCGGAGTCTTGGCAGGAGCAAAACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References