183707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1557112..1557911 Replicon chromosome
Accession NZ_CP065970
Organism Escherichia coli strain FDAARGOS_1058

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag I6I15_RS08095 Protein ID WP_000347251.1
Coordinates 1557112..1557576 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag I6I15_RS08100 Protein ID WP_001307405.1
Coordinates 1557576..1557911 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I15_RS08065 1552113..1552547 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
I6I15_RS08070 1552565..1553443 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
I6I15_RS08075 1553433..1554212 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
I6I15_RS08080 1554223..1554696 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
I6I15_RS08085 1554719..1555999 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
I6I15_RS08090 1556248..1557057 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
I6I15_RS08095 1557112..1557576 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
I6I15_RS08100 1557576..1557911 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
I6I15_RS08105 1558060..1559631 - 1572 WP_001273761.1 galactarate dehydratase -
I6I15_RS08110 1560006..1561340 + 1335 WP_000599653.1 galactarate/glucarate/glycerate transporter GarP -
I6I15_RS08115 1561356..1562126 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T183707 WP_000347251.1 NZ_CP065970:c1557576-1557112 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T183707 NZ_CP087166:478347-478652 [Pseudomonas sp. B21-051]
ATGCCCGAGATCATTCGAAGTTCAACATTCTCCACCTGGCTTTTGAAGCTGGCTGACAACCGCGCCAGGTTGCGTATTCA
GGTGCGCATTGATCGTATGGCCGATGGGAATTTTGGTGATGTCAAAGCCGTCGGTGAGGGGCTCAGCGAAGTCAGAATTG
ACTATGGCCCCGGATATCGAGTCTATTTCATGCAACAAGGTCGGCAAGTGGTCATCCTCCTTTGTGGTGGAGACAAGAGC
AGCCAACCCCGAGATATCAAGCAAGCCAGGCTCATCGCGGAGTCTTGGCAGGAGCAAAACCCATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT183707 WP_001307405.1 NZ_CP065970:c1557911-1557576 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT183707 NZ_CP087166:478649-478936 [Pseudomonas sp. B21-051]
ATGACCGAACAATTCACTCGTTGGGACTCAGCCGAGTACCTCAAGACAGAAGAGGACATGGCCAATTATCTGGATGCCTG
CATGGAGGAGGCTGGAGATGATCCTGCCTTTATCGCCAAGGCACTGGGCACCATTGCGAGAGCGCGAGGCATGACCCAAG
TCGCACGTGACGCCGGGCTGTCTCGAGAAAGTCTCTACCGTGCACTGTCAGGTGAAGGAAATCCTGAGTTTGGAACGATT
CTGAAAGTGGTGAAGGCGTTGGGCTTGAAGTTACATGCCAGCACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References