Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 99588..99841 | Replicon | plasmid pKP2509-KPC |
| Accession | NZ_CP065952 | ||
| Organism | Klebsiella pneumoniae strain KP2509 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | JDE60_RS28130 | Protein ID | WP_001312851.1 |
| Coordinates | 99692..99841 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 99588..99647 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JDE60_RS28090 (94589) | 94589..95293 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| JDE60_RS28095 (95318) | 95318..95518 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| JDE60_RS28100 (95538) | 95538..96284 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| JDE60_RS28105 (96339) | 96339..96899 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| JDE60_RS28110 (97031) | 97031..97231 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| JDE60_RS28115 (97764) | 97764..98461 | + | 698 | WP_223174630.1 | IS1 family transposase | - |
| JDE60_RS28120 (98526) | 98526..98993 | + | 468 | WP_266098392.1 | PIN domain-containing protein | - |
| JDE60_RS28125 (99055) | 99055..99387 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (99588) | 99588..99647 | - | 60 | NuclAT_0 | - | Antitoxin |
| - (99588) | 99588..99647 | - | 60 | NuclAT_0 | - | Antitoxin |
| - (99588) | 99588..99647 | - | 60 | NuclAT_0 | - | Antitoxin |
| - (99588) | 99588..99647 | - | 60 | NuclAT_0 | - | Antitoxin |
| JDE60_RS28130 (99692) | 99692..99841 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| JDE60_RS28135 (100125) | 100125..100373 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| JDE60_RS30420 (100488) | 100488..100672 | + | 185 | Protein_138 | protein CopA/IncA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaCTX-M-65 / blaSHV-12 / blaKPC-2 / catA2 | - | 1..100684 | 100684 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T183683 WP_001312851.1 NZ_CP065952:99692-99841 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T183683 NZ_CP087151:c5395735-5395352 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 60 bp
>AT183683 NZ_CP065952:c99647-99588 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
