Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 4291392..4291987 Replicon chromosome
Accession NZ_CP065948
Organism Pseudomonas aeruginosa strain PAM68

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag JBL37_RS20320 Protein ID WP_003117425.1
Coordinates 4291709..4291987 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JBL37_RS20315 Protein ID WP_003099268.1
Coordinates 4291392..4291697 (-) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JBL37_RS20280 (JBL37_20285) 4286541..4287389 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
JBL37_RS20290 (JBL37_20295) 4287556..4288497 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
JBL37_RS20295 (JBL37_20300) 4288614..4289228 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
JBL37_RS20300 (JBL37_20305) 4289270..4289854 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
JBL37_RS20305 (JBL37_20310) 4289895..4290995 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
JBL37_RS20315 (JBL37_20320) 4291392..4291697 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
JBL37_RS20320 (JBL37_20325) 4291709..4291987 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JBL37_RS30970 4292040..4292168 - 129 Protein_4023 integrase -
JBL37_RS20325 (JBL37_20330) 4292316..4294544 + 2229 WP_003099265.1 TonB-dependent receptor -
JBL37_RS20330 (JBL37_20335) 4294614..4295261 - 648 WP_003095021.1 carbonate dehydratase -
JBL37_RS20335 (JBL37_20340) 4295323..4296561 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-92)

Antitoxin

(1-97)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T183663 WP_003117425.1 NZ_CP065948:c4291987-4291709 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T183663 NZ_CP087146:c4811156-4810623 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT183663 WP_003099268.1 NZ_CP065948:c4291697-4291392 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT183663 NZ_CP087146:c4811433-4811167 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5


Antitoxin

Source ID Structure

References