Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4362394..4363112 Replicon chromosome
Accession NZ_CP065946
Organism Pectobacterium parmentieri strain WC19161

Toxin (Protein)


Gene name higB Uniprot ID A0A8B3FNM7
Locus tag JBL47_RS19850 Protein ID WP_033070820.1
Coordinates 4362807..4363112 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JBL47_RS19845 Protein ID WP_198337904.1
Coordinates 4362394..4362810 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JBL47_RS19825 4357742..4358188 - 447 WP_012822200.1 helix-turn-helix transcriptional regulator -
JBL47_RS19830 4358343..4359614 + 1272 WP_198481877.1 MFS transporter -
JBL47_RS19835 4359645..4360997 + 1353 WP_198481878.1 aspartate aminotransferase family protein -
JBL47_RS19840 4361078..4361536 - 459 WP_012822197.1 hypothetical protein -
JBL47_RS19845 4362394..4362810 - 417 WP_198337904.1 helix-turn-helix domain-containing protein Antitoxin
JBL47_RS19850 4362807..4363112 - 306 WP_033070820.1 type II toxin-antitoxin system HigB family toxin Toxin
JBL47_RS19855 4363264..4363524 + 261 WP_198481879.1 type II toxin-antitoxin system RelE/ParE family toxin -
JBL47_RS19860 4363598..4363969 + 372 WP_012822192.1 helix-turn-helix domain-containing protein -
JBL47_RS19865 4365564..4365857 - 294 WP_005973730.1 type I-E CRISPR-associated endoribonuclease Cas2 -
JBL47_RS19870 4365858..4366775 - 918 WP_012822191.1 type I-E CRISPR-associated endonuclease Cas1 -
JBL47_RS19875 4366803..4367450 - 648 WP_014698580.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(18-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12010.78 Da        Isoelectric Point: 10.0386

>T183654 WP_033070820.1 NZ_CP065946:c4363112-4362807 [Pectobacterium parmentieri]
VFSRAPFDTAIAQFPNQAAALADLYRTIKREIYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKIFI
KHITSHAEYGSLTEYYRRNKE

Download         Length: 306 bp

>T183654 NZ_CP087144:132122-132271 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15371.68 Da        Isoelectric Point: 4.5667

>AT183654 WP_198337904.1 NZ_CP065946:c4362810-4362394 [Pectobacterium parmentieri]
MMYADAIKAANNLTSIVPLLGGSTSRKDYEDALKLTEYLLESEPDSPLIDMLTAKIDKYEEDAPEFVAFNERIKALPAGI
ALLRILMDQHGLTQSDFEAEIGKKSLVSRILNGERTLTLDHMRALAKRFDIPVSAFID

Download         Length: 417 bp

>AT183654 NZ_CP087144:c132077-132018 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3FNM7

Antitoxin

Source ID Structure

References