Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 38349..38868 | Replicon | plasmid p5_45kb |
Accession | NZ_CP065932 | ||
Organism | Enterococcus faecium strain Dallas 5 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | JCP67_RS15450 | Protein ID | WP_000588503.1 |
Coordinates | 38611..38868 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | JCP67_RS15445 | Protein ID | WP_000388479.1 |
Coordinates | 38349..38618 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JCP67_RS15420 | 33598..35043 | + | 1446 | Protein_37 | type I restriction-modification system subunit M | - |
JCP67_RS15425 | 35099..35779 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
JCP67_RS15430 | 36336..37016 | - | 681 | WP_002287920.1 | IS6-like element IS1216 family transposase | - |
JCP67_RS15435 | 37092..37658 | + | 567 | Protein_40 | hypothetical protein | - |
JCP67_RS15440 | 38039..38218 | + | 180 | WP_001120991.1 | hypothetical protein | - |
JCP67_RS15445 | 38349..38618 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
JCP67_RS15450 | 38611..38868 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
JCP67_RS15455 | 39327..40331 | + | 1005 | WP_000455809.1 | hypothetical protein | - |
JCP67_RS15460 | 40496..41110 | - | 615 | WP_001261742.1 | recombinase family protein | - |
JCP67_RS15465 | 41560..42885 | + | 1326 | WP_000969590.1 | Y-family DNA polymerase | - |
JCP67_RS15470 | 42878..43228 | + | 351 | WP_000568378.1 | hypothetical protein | - |
JCP67_RS15475 | 43225..43404 | + | 180 | WP_001021554.1 | hypothetical protein | - |
JCP67_RS15480 | 43540..43830 | + | 291 | WP_000026576.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Non-Mobilizable plasmid | erm(B) / ant(6)-Ia / aph(3')-III / VanHAX | - | 1..45647 | 45647 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T183621 WP_000588503.1 NZ_CP065932:38611-38868 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T183621 NZ_CP087136:c2083493-2083239 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT183621 WP_000388479.1 NZ_CP065932:38349-38618 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT183621 NZ_CP087136:c2083741-2083490 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |