183621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 38349..38868 Replicon plasmid p5_45kb
Accession NZ_CP065932
Organism Enterococcus faecium strain Dallas 5

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP67_RS15450 Protein ID WP_000588503.1
Coordinates 38611..38868 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP67_RS15445 Protein ID WP_000388479.1
Coordinates 38349..38618 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP67_RS15420 33598..35043 + 1446 Protein_37 type I restriction-modification system subunit M -
JCP67_RS15425 35099..35779 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP67_RS15430 36336..37016 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP67_RS15435 37092..37658 + 567 Protein_40 hypothetical protein -
JCP67_RS15440 38039..38218 + 180 WP_001120991.1 hypothetical protein -
JCP67_RS15445 38349..38618 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP67_RS15450 38611..38868 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP67_RS15455 39327..40331 + 1005 WP_000455809.1 hypothetical protein -
JCP67_RS15460 40496..41110 - 615 WP_001261742.1 recombinase family protein -
JCP67_RS15465 41560..42885 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP67_RS15470 42878..43228 + 351 WP_000568378.1 hypothetical protein -
JCP67_RS15475 43225..43404 + 180 WP_001021554.1 hypothetical protein -
JCP67_RS15480 43540..43830 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..45647 45647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T183621 WP_000588503.1 NZ_CP065932:38611-38868 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T183621 NZ_CP087136:c2083493-2083239 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT183621 WP_000388479.1 NZ_CP065932:38349-38618 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT183621 NZ_CP087136:c2083741-2083490 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References