Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 107050..107585 Replicon plasmid p5_126kb
Accession NZ_CP065929
Organism Enterococcus faecium strain Dallas 5

Toxin (Protein)


Gene name yoeB Uniprot ID Q3Y221
Locus tag JCP67_RS14430 Protein ID WP_002305108.1
Coordinates 107050..107322 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A133CED7
Locus tag JCP67_RS14435 Protein ID WP_002303154.1
Coordinates 107322..107585 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP67_RS14400 102060..103247 - 1188 WP_002303156.1 NADP-dependent malic enzyme -
JCP67_RS14405 103435..104382 + 948 WP_002303155.1 DNA-binding transcriptional regulator -
JCP67_RS14410 104675..105223 - 549 WP_002292681.1 hypothetical protein -
JCP67_RS14415 105224..106081 - 858 WP_002292680.1 AAA family ATPase -
JCP67_RS14420 106367..106654 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
JCP67_RS14425 106644..106973 - 330 WP_002292678.1 AbrB family transcriptional regulator -
JCP67_RS14430 107050..107322 - 273 WP_002305108.1 Txe/YoeB family addiction module toxin Toxin
JCP67_RS14435 107322..107585 - 264 WP_002303154.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP67_RS14440 107691..108107 - 417 WP_002303153.1 hypothetical protein -
JCP67_RS14445 108113..108676 - 564 Protein_118 IS6 family transposase -
JCP67_RS14450 108756..109918 + 1163 WP_102642289.1 IS3 family transposase -
JCP67_RS14455 110416..111096 - 681 WP_002319817.1 IS6-like element ISS1N family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..126296 126296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10806.28 Da        Isoelectric Point: 9.9080

>T183619 WP_002305108.1 NZ_CP065929:c107322-107050 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T183619 NZ_CP087136:c1918011-1917908 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9886.16 Da        Isoelectric Point: 4.5370

>AT183619 WP_002303154.1 NZ_CP065929:c107585-107322 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT183619 NZ_CP087136:1917870-1918141 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133CER3

Antitoxin

Source ID Structure
AlphaFold DB A0A133CED7

References