Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 195356..195879 Replicon chromosome
Accession NZ_CP065926
Organism Staphylococcus pseudintermedius strain SP_9261-1A

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JC283_RS00865 Protein ID WP_015729746.1
Coordinates 195613..195879 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2P5PI69
Locus tag JC283_RS00860 Protein ID WP_015729747.1
Coordinates 195356..195613 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC283_RS00845 191404..192210 + 807 WP_114281618.1 arylamine N-acetyltransferase -
JC283_RS00850 192504..192998 - 495 WP_015729749.1 membrane protein -
JC283_RS00855 193258..195162 + 1905 WP_198458713.1 triacylglycerol lipase -
JC283_RS00860 195356..195613 + 258 WP_015729747.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JC283_RS00865 195613..195879 + 267 WP_015729746.1 Txe/YoeB family addiction module toxin Toxin
JC283_RS00870 196375..197694 + 1320 WP_015729285.1 ISL3 family transposase -
JC283_RS00875 197732..197833 - 102 WP_019169745.1 DUF2648 domain-containing protein -
JC283_RS00880 197847..199340 - 1494 WP_014612817.1 malate dehydrogenase (quinone) -
JC283_RS00885 200097..200198 + 102 Protein_174 KxYKxGKxW signal peptide domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10541.08 Da        Isoelectric Point: 10.1602

>T183612 WP_015729746.1 NZ_CP065926:195613-195879 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKVNPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Download         Length: 267 bp

>T183612 NZ_CP087136:c1265278-1265171 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9836.85 Da        Isoelectric Point: 4.1100

>AT183612 WP_015729747.1 NZ_CP065926:195356-195613 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT183612 NZ_CP087136:1265326-1265392 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2P5PI69

References