Detailed information of TA system TA183608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 169283..169806
• Replicon: chromosome
• Accession: NZ_CP065925
• Organism: Staphylococcus pseudintermedius strain SP_11304-1A

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JC282_RS00725
• Protein ID: WP_198455063.1
• Coordinates: 169540..169806 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2P5PI69
• Locus tag: JC282_RS00720
• Protein ID: WP_015729747.1
• Coordinates: 169283..169540 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC282_RS00700	164622..164804	-	183	WP_063278657.1	hypothetical protein	-
JC282_RS00705	165331..166119	+	789	WP_063278656.1	arylamine N-acetyltransferase	-
JC282_RS00710	166431..166925	-	495	WP_037542124.1	membrane protein	-
JC282_RS00715	167185..169089	+	1905	WP_198455062.1	triacylglycerol lipase	-
JC282_RS00720	169283..169540	+	258	WP_015729747.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JC282_RS00725	169540..169806	+	267	WP_198455063.1	Txe/YoeB family addiction module toxin	Toxin
JC282_RS00730	170166..170267	-	102	WP_019169745.1	DUF2648 domain-containing protein	-
JC282_RS00735	170281..171774	-	1494	WP_014612817.1	malate dehydrogenase (quinone)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10521.09 Da
• Isoelectric Point: 10.1602

>T183608 WP_198455063.1 NZ_CP065925:169540-169806 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQISKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Nucleotide

• Length: 267 bp

>T183608 NZ_CP087136:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9836.85 Da
• Isoelectric Point: 4.1100

>AT183608 WP_015729747.1 NZ_CP065925:169283-169540 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT183608 NZ_CP087136:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2P5PI69