Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 242751..243274 Replicon chromosome
Accession NZ_CP065924
Organism Staphylococcus pseudintermedius strain SP_11304-2A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A317Z6J3
Locus tag JC285_RS01115 Protein ID WP_037542127.1
Coordinates 243008..243274 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2P5PI69
Locus tag JC285_RS01110 Protein ID WP_015729747.1
Coordinates 242751..243008 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC285_RS01090 238088..238270 - 183 WP_041613203.1 hypothetical protein -
JC285_RS01095 238800..239588 + 789 WP_063284837.1 arylamine N-acetyltransferase -
JC285_RS01100 239900..240394 - 495 WP_015729749.1 membrane protein -
JC285_RS01105 240654..242557 + 1904 Protein_218 triacylglycerol lipase -
JC285_RS01110 242751..243008 + 258 WP_015729747.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JC285_RS01115 243008..243274 + 267 WP_037542127.1 Txe/YoeB family addiction module toxin Toxin
JC285_RS01120 243635..243736 - 102 WP_019169745.1 DUF2648 domain-containing protein -
JC285_RS01125 243750..245243 - 1494 WP_014612817.1 malate dehydrogenase (quinone) -
JC285_RS01130 246000..246101 + 102 Protein_223 KxYKxGKxW signal peptide domain-containing protein -
JC285_RS01135 247534..248043 - 510 WP_172635591.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10555.10 Da        Isoelectric Point: 10.1602

>T183605 WP_037542127.1 NZ_CP065924:243008-243274 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Download         Length: 267 bp

>T183605 NZ_CP087124:c2507964-2507704 [Sulfurovum sp. HSL1-3]
ATGATCATCGGATTTGCTGATAGGGGATGGGAAGATTATCAGTATTGGGTCCATAATGACAAAAAAATCGTAAAAAGAAT
CAACCTTTTATTGCAGGATATCAAAAGAAATCCGGATGATTCAAATGGATTGGGTAGACCGGAGAGACTGAAAGAGAATT
TTCAGGGATATTTTTCTCGAAGAATCACCTCTGAGCATAGACTTGTTTATAAAATCATTGAAGATATCATCGTTGTGGCA
CAGTGTAGATATCATTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9836.85 Da        Isoelectric Point: 4.1100

>AT183605 WP_015729747.1 NZ_CP065924:242751-243008 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT183605 NZ_CP087124:c2508212-2507961 [Sulfurovum sp. HSL1-3]
ATGCAAGCTGTTTTTTATTCACAGGCAAGAAATAACCTAAGGGATATTATCAATAAAGTATGTGATGATTTTGATGAGTA
TATCATTACTACAAAAGATAATAAATCTGCTGTCATACTTTCGTATGAAGAGTACAGTGCAATGAAAGAGACGATGTATC
TTCTTGCATCAAAAAATAACAGAGAGAGATTGAATGATGCGGTAGAGCAGATAGAGAATGCAGCATTCATAAAAAAAGAT
ATCGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A317Z6J3

Antitoxin

Source ID Structure
AlphaFold DB A0A2P5PI69

References