Detailed information of TA system TA183602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 178715..179238
• Replicon: chromosome
• Accession: NZ_CP065921
• Organism: Staphylococcus pseudintermedius strain SP_11304-3A

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JC286_RS00790
• Protein ID: WP_063278654.1
• Coordinates: 178972..179238 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JC286_RS00785
• Protein ID: WP_198461263.1
• Coordinates: 178715..178972 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC286_RS00765	174054..174236	-	183	WP_063278657.1	hypothetical protein	-
JC286_RS00770	174763..175569	+	807	WP_198461261.1	arylamine N-acetyltransferase	-
JC286_RS00775	175863..176357	-	495	WP_015729749.1	membrane protein	-
JC286_RS00780	176617..178521	+	1905	WP_143951594.1	triacylglycerol lipase	-
JC286_RS00785	178715..178972	+	258	WP_198461263.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JC286_RS00790	178972..179238	+	267	WP_063278654.1	Txe/YoeB family addiction module toxin	Toxin
JC286_RS00795	179599..179700	-	102	WP_019169745.1	DUF2648 domain-containing protein	-
JC286_RS00800	179714..181207	-	1494	WP_014612817.1	malate dehydrogenase (quinone)	-
JC286_RS00805	181964..182065	+	102	Protein_159	KxYKxGKxW signal peptide domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10539.11 Da
• Isoelectric Point: 10.2281

>T183602 WP_063278654.1 NZ_CP065921:178972-179238 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKPLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Nucleotide

• Length: 267 bp

>T183602 NZ_CP087123:5525726-5526196 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9880.90 Da
• Isoelectric Point: 4.1207

>AT183602 WP_198461263.1 NZ_CP065921:178715-178972 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIEDI
DWDNL

Nucleotide

• Length: 258 bp

>AT183602 NZ_CP087123:5525286-5525729 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA