183599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 185879..186402 Replicon chromosome
Accession NZ_CP065920
Organism Staphylococcus pseudintermedius strain SP_11306-1A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A317Z6J3
Locus tag JC281_RS00800 Protein ID WP_037542127.1
Coordinates 186136..186402 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2P5PI69
Locus tag JC281_RS00795 Protein ID WP_015729747.1
Coordinates 185879..186136 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC281_RS00775 181217..181399 - 183 WP_096536006.1 hypothetical protein -
JC281_RS00780 181927..182733 + 807 WP_198456124.1 arylamine N-acetyltransferase -
JC281_RS00785 183027..183521 - 495 WP_015729749.1 membrane protein -
JC281_RS00790 183781..185685 + 1905 WP_198456125.1 triacylglycerol lipase -
JC281_RS00795 185879..186136 + 258 WP_015729747.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JC281_RS00800 186136..186402 + 267 WP_037542127.1 Txe/YoeB family addiction module toxin Toxin
JC281_RS00805 186762..186863 - 102 WP_019169745.1 DUF2648 domain-containing protein -
JC281_RS00810 186877..188370 - 1494 WP_014612817.1 malate dehydrogenase (quinone) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10555.10 Da        Isoelectric Point: 10.1602

>T183599 WP_037542127.1 NZ_CP065920:186136-186402 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Download         Length: 267 bp

>T183599 NZ_CP087123:c4915530-4915246 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9836.85 Da        Isoelectric Point: 4.1100

>AT183599 WP_015729747.1 NZ_CP065920:185879-186136 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT183599 NZ_CP087123:c4915762-4915520 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A317Z6J3

Antitoxin

Source ID Structure
AlphaFold DB A0A2P5PI69

References