Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3552335..3553029 Replicon chromosome
Accession NZ_CP065918
Organism Yersinia pestis EV NIIEG

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag AH66_RS16005 Protein ID WP_002214787.1
Coordinates 3552335..3552631 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag AH66_RS16010 Protein ID WP_002209924.1
Coordinates 3552631..3553029 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH66_RS15975 3547457..3548974 + 1518 WP_002209930.1 lysine--tRNA ligase -
AH66_RS15985 3549407..3550621 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
AH66_RS15990 3550703..3550888 - 186 WP_002209928.1 hypothetical protein -
AH66_RS15995 3551486..3551746 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
AH66_RS16000 3551809..3552171 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
AH66_RS16005 3552335..3552631 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
AH66_RS16010 3552631..3553029 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
AH66_RS16015 3553429..3555724 - 2296 Protein_3110 toprim domain-containing protein -
AH66_RS16020 3556024..3556350 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
AH66_RS16025 3556343..3556495 + 153 WP_002209921.1 hypothetical protein -
AH66_RS16030 3556509..3556709 - 201 WP_002209920.1 AlpA family transcriptional regulator -
AH66_RS16035 3556891..3557223 - 333 WP_002214791.1 hypothetical protein -
AH66_RS16040 3557229..3557465 - 237 WP_002214792.1 hypothetical protein -
AH66_RS16045 3557478..3557843 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T183595 WP_002214787.1 NZ_CP065918:3552335-3552631 [Yersinia pestis EV NIIEG]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T183595 NZ_CP087123:2075692-2075794 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT183595 WP_002209924.1 NZ_CP065918:3552631-3553029 [Yersinia pestis EV NIIEG]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT183595 NZ_CP087123:c2075801-2075656 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References