Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5629839..5630434 Replicon chromosome
Accession NZ_CP065867
Organism Pseudomonas aeruginosa strain TJ2014-049

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I9X29_RS26180 Protein ID WP_079388883.1
Coordinates 5630156..5630434 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I9X29_RS26175 Protein ID WP_003133769.1
Coordinates 5629839..5630144 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X29_RS26150 5624883..5625983 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
I9X29_RS26155 5626068..5627111 - 1044 WP_049321234.1 lipase secretion chaperone -
I9X29_RS26160 5627191..5628117 - 927 WP_009316208.1 triacylglycerol lipase -
I9X29_RS26165 5628412..5629542 + 1131 WP_057384474.1 AraC family transcriptional regulator ligand-binding domain-containing protein -
I9X29_RS26175 5629839..5630144 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
I9X29_RS26180 5630156..5630434 - 279 WP_079388883.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I9X29_RS26185 5630763..5632991 + 2229 WP_198340928.1 TonB-dependent receptor -
I9X29_RS26190 5633062..5633709 - 648 WP_003095021.1 carbonate dehydratase -
I9X29_RS26195 5633771..5635009 - 1239 WP_074222665.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10676.28 Da        Isoelectric Point: 7.8937

>T183579 WP_079388883.1 NZ_CP065867:c5630434-5630156 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAMELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T183579 NZ_CP087122:1729007-1729339 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGCGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT183579 WP_003133769.1 NZ_CP065867:c5630144-5629839 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT183579 NZ_CP087122:1728749-1729006 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References