Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4927018..4927699 Replicon chromosome
Accession NZ_CP065867
Organism Pseudomonas aeruginosa strain TJ2014-049

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I9X29_RS22965 Protein ID WP_031639878.1
Coordinates 4927334..4927699 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I9X29_RS22960 Protein ID WP_003145733.1
Coordinates 4927018..4927341 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X29_RS22935 4922948..4923586 + 639 WP_003109444.1 hypothetical protein -
I9X29_RS22940 4923827..4924162 + 336 WP_003119438.1 TM2 domain-containing protein -
I9X29_RS22945 4924336..4924854 + 519 WP_058166636.1 PAAR domain-containing protein -
I9X29_RS22950 4924851..4925549 + 699 WP_058166637.1 VRR-NUC domain-containing protein -
I9X29_RS22955 4925566..4926654 + 1089 WP_058200297.1 DUF3396 domain-containing protein -
I9X29_RS22960 4927018..4927341 - 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
I9X29_RS22965 4927334..4927699 - 366 WP_031639878.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I9X29_RS22970 4927962..4928204 - 243 WP_128697741.1 hypothetical protein -
I9X29_RS22975 4928410..4928682 + 273 WP_057385560.1 hypothetical protein -
I9X29_RS22980 4928713..4929138 - 426 WP_003116492.1 VOC family protein -
I9X29_RS22985 4929239..4930123 + 885 WP_198340865.1 LysR family transcriptional regulator -
I9X29_RS22990 4930096..4931049 - 954 WP_003085661.1 LysR family transcriptional regulator -
I9X29_RS22995 4931270..4931704 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4923827..4930123 6296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13970.32 Da        Isoelectric Point: 4.8219

>T183578 WP_031639878.1 NZ_CP065867:c4927699-4927334 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSDINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDYRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T183578 NZ_CP087122:794914-795324 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT183578 WP_003145733.1 NZ_CP065867:c4927341-4927018 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT183578 NZ_CP087122:794667-794933 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References