Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2541627..2542150 Replicon chromosome
Accession NZ_CP065857
Organism Staphylococcus aureus strain CC1153-MRSA

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag I1A60_RS12605 Protein ID WP_000074045.1
Coordinates 2541627..2541893 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag I1A60_RS12610 Protein ID WP_000587619.1
Coordinates 2541893..2542150 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A60_RS12585 2536935..2538122 - 1188 WP_072468572.1 MFS transporter -
I1A60_RS12590 2538516..2539292 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
I1A60_RS12595 2539285..2539947 - 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
I1A60_RS12600 2540195..2541271 - 1077 WP_001076671.1 M42 family metallopeptidase -
I1A60_RS12605 2541627..2541893 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
I1A60_RS12610 2541893..2542150 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I1A60_RS12615 2542510..2542965 + 456 WP_000732082.1 DUF1307 domain-containing protein -
I1A60_RS12620 2543133..2544710 - 1578 WP_000143502.1 FMN-binding glutamate synthase family protein -
I1A60_RS12625 2544905..2545654 + 750 WP_000072462.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T183553 WP_000074045.1 NZ_CP065857:c2541893-2541627 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T183553 NZ_CP087110:3537224-3537502 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT183553 WP_000587619.1 NZ_CP065857:c2542150-2541893 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT183553 NZ_CP087110:3536961-3537221 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References