Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2510029..2510213 Replicon chromosome
Accession NZ_CP065857
Organism Staphylococcus aureus strain CC1153-MRSA

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag I1A60_RS12460 Protein ID WP_000482647.1
Coordinates 2510106..2510213 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2510029..2510089 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A60_RS12445 2505483..2505650 - 168 Protein_2405 hypothetical protein -
I1A60_RS12450 2505881..2507614 - 1734 WP_072468586.1 ABC transporter ATP-binding protein/permease -
I1A60_RS12455 2507639..2509402 - 1764 WP_072468585.1 ABC transporter ATP-binding protein/permease -
- 2510029..2510089 + 61 - - Antitoxin
I1A60_RS12460 2510106..2510213 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
I1A60_RS12465 2510347..2510733 - 387 WP_000779360.1 flippase GtxA -
I1A60_RS12470 2510991..2512133 + 1143 WP_072468584.1 glycerate kinase -
I1A60_RS12475 2512193..2512852 + 660 WP_000831298.1 membrane protein -
I1A60_RS12480 2513034..2514245 + 1212 WP_072468583.1 multidrug effflux MFS transporter -
I1A60_RS12485 2514368..2514841 - 474 WP_198051142.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T183551 WP_000482647.1 NZ_CP065857:c2510213-2510106 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T183551 NZ_CP087110:3316375-3316593 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT183551 NZ_CP065857:2510029-2510089 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References