Detailed information of TA system TA183548

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2233483..2233699
• Replicon: chromosome
• Accession: NZ_CP065857
• Organism: Staphylococcus aureus strain CC1153-MRSA

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: I1A60_RS11010
• Protein ID: WP_072468699.1
• Coordinates: 2233595..2233699 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2233483..2233538 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1A60_RS10990	2229620..2230285	-	666	WP_001024095.1	SDR family oxidoreductase	-
I1A60_RS10995	2230437..2230757	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I1A60_RS11000	2230759..2231739	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
I1A60_RS11005	2232005..2233096	+	1092	WP_033859799.1	lytic regulatory protein	-
-	2233483..2233538	+	56	-	-	Antitoxin
I1A60_RS11010	2233595..2233699	-	105	WP_072468699.1	hypothetical protein	Toxin
I1A60_RS11015	2234216..2234386	+	171	WP_001792292.1	transposase	-
I1A60_RS11020	2234379..2234537	+	159	WP_001792784.1	hypothetical protein	-
I1A60_RS11025	2235195..2236052	-	858	WP_000370929.1	Cof-type HAD-IIB family hydrolase	-
I1A60_RS11030	2236120..2236902	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3936.80 Da
• Isoelectric Point: 5.5724

>T183548 WP_072468699.1 NZ_CP065857:c2233699-2233595 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIISLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T183548 NZ_CP087110:2474979-2475086 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT183548 NZ_CP065857:2233483-2233538 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin