Detailed information of TA system TA183540

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1900691..1900873
• Replicon: chromosome
• Accession: NZ_CP065857
• Organism: Staphylococcus aureus strain CC1153-MRSA

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: I1A60_RS09175
• Protein ID: WP_001801861.1
• Coordinates: 1900691..1900786 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1900814..1900873 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1A60_RS09135	1896362..1896988	+	627	WP_072468072.1	hypothetical protein	-
I1A60_RS09140	1897029..1897370	+	342	WP_000627540.1	DUF3969 family protein	-
I1A60_RS09145	1897471..1898043	+	573	WP_000414215.1	hypothetical protein	-
I1A60_RS09150	1898241..1898798	-	558	WP_072468071.1	ImmA/IrrE family metallo-endopeptidase	-
I1A60_RS09155	1898984..1899169	-	186	WP_072468070.1	hypothetical protein	-
I1A60_RS09160	1899171..1899347	-	177	WP_000375476.1	hypothetical protein	-
I1A60_RS09165	1899358..1899741	-	384	WP_000070811.1	hypothetical protein	-
I1A60_RS09170	1900345..1900488	-	144	WP_072468069.1	transposase	-
I1A60_RS09175	1900691..1900786	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1900814..1900873	-	60	-	-	Antitoxin
I1A60_RS09180	1900909..1901010	+	102	WP_001791893.1	hypothetical protein	-
I1A60_RS09185	1900988..1901164	-	177	Protein_1807	transposase	-
I1A60_RS09190	1901358..1901735	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1893804..1945822	52018

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T183540 WP_001801861.1 NZ_CP065857:1900691-1900786 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T183540 NZ_CP087110:c976159-975086 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT183540 NZ_CP065857:c1900873-1900814 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin