183530

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1764338..1764933 Replicon chromosome
Accession NZ_CP065848
Organism Pseudomonas aeruginosa strain CMC-097

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAU57_RS08165 Protein ID WP_071536079.1
Coordinates 1764338..1764616 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAU57_RS08170 Protein ID WP_003099268.1
Coordinates 1764628..1764933 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU57_RS08150 1759764..1761002 + 1239 WP_017001387.1 C69 family dipeptidase -
IAU57_RS08155 1761064..1761711 + 648 WP_003095021.1 carbonate dehydratase -
IAU57_RS08160 1761781..1764009 - 2229 WP_031689776.1 TonB-dependent receptor -
IAU57_RS08165 1764338..1764616 + 279 WP_071536079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAU57_RS08170 1764628..1764933 + 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
IAU57_RS08175 1765270..1765662 + 393 WP_049951329.1 hypothetical protein -
IAU57_RS08180 1765723..1766814 - 1092 WP_124132249.1 hypothetical protein -
IAU57_RS08185 1766867..1767202 - 336 WP_031689774.1 hypothetical protein -
IAU57_RS08190 1767258..1767524 - 267 WP_023088595.1 hypothetical protein -
IAU57_RS08195 1767634..1767906 + 273 WP_004352675.1 hypothetical protein -
IAU57_RS08200 1768082..1768369 + 288 WP_031689773.1 DUF5447 family protein -
IAU57_RS08205 1768377..1769021 + 645 WP_031689772.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10632.17 Da        Isoelectric Point: 7.8937

>T183530 WP_071536079.1 NZ_CP065848:1764338-1764616 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T183530 NZ_CP087103:234507-234857 [Bacillus toyonensis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTATGGATTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGATTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT183530 WP_003099268.1 NZ_CP065848:1764628-1764933 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT183530 NZ_CP087103:234215-234502 [Bacillus toyonensis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACGGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References