Detailed information of TA system TA183367

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2894398..2894735
• Replicon: chromosome
• Accession: NZ_CP065784
• Organism: Enterococcus faecalis strain 18-243

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A8B3RXG6
• Locus tag: I8F59_RS14280
• Protein ID: WP_010710015.1
• Coordinates: 2894398..2894541 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2894473..2894735 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8F59_RS14260	2890556..2891194	-	639	WP_142954328.1	lytic polysaccharide monooxygenase	-
I8F59_RS14265	2891879..2893495	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
I8F59_RS14270	2893729..2893911	+	183	WP_002424907.1	type I toxin-antitoxin system toxin PepG1	-
I8F59_RS14275	2894030..2894170	+	141	WP_073340360.1	putative holin-like toxin	-
I8F59_RS14280	2894398..2894541	+	144	WP_010710015.1	putative holin-like toxin	Toxin
-	2894473..2894735	-	263	-	-	Antitoxin
I8F59_RS14285	2894736..2899427	-	4692	WP_025186410.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5191.13 Da
• Isoelectric Point: 8.6626

>T183367 WP_010710015.1 NZ_CP065784:2894398-2894541 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLTFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T183367 NZ_CP086936:5028-5303 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin

Nucleotide

• Length: 263 bp

>AT183367 NZ_CP065784:c2894735-2894473 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGATCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGGTT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A8B3RXG6

Antitoxin