Detailed information of TA system TA183355

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2893729..2894028
• Replicon: chromosome
• Accession: NZ_CP065784
• Organism: Enterococcus faecalis strain 18-243

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A8B3RWV6
• Locus tag: I8F59_RS14270
• Protein ID: WP_002424907.1
• Coordinates: 2893729..2893911 (+)
• Length: 61 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2893844..2894028 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8F59_RS14250	2888946..2889161	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
I8F59_RS14255	2889300..2890292	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
I8F59_RS14260	2890556..2891194	-	639	WP_142954328.1	lytic polysaccharide monooxygenase	-
I8F59_RS14265	2891879..2893495	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
I8F59_RS14270	2893729..2893911	+	183	WP_002424907.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2893844..2894028	-	185	-	-	Antitoxin
I8F59_RS14275	2894030..2894170	+	141	WP_073340360.1	putative holin-like toxin	-
I8F59_RS14280	2894398..2894541	+	144	WP_010710015.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (27-60)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6952.45 Da
• Isoelectric Point: 11.0738

>T183355 WP_002424907.1 NZ_CP065784:2893729-2893911 [Enterococcus faecalis]
MAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 183 bp

>T183355 NZ_CP086922:c188650-188399 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin

Nucleotide

• Length: 185 bp

>AT183355 NZ_CP065784:c2894028-2893844 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A8B3RWV6

Antitoxin