Detailed information of TA system TA183352

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2727681..2728166
• Replicon: chromosome
• Accession: NZ_CP065784
• Organism: Enterococcus faecalis strain 18-243

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: I8F59_RS13545
• Protein ID: WP_021164441.1
• Coordinates: 2727681..2727782 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2727957..2728166 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8F59_RS13520	2723209..2724162	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
I8F59_RS13525	2724201..2724956	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
I8F59_RS13530	2724953..2725918	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
I8F59_RS13535	2725915..2726862	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
I8F59_RS13540	2727047..2727499	+	453	WP_002359057.1	YueI family protein	-
I8F59_RS13545	2727681..2727782	-	102	WP_021164441.1	putative holin-like toxin	Toxin
-	2727957..2728166	+	210	-	-	Antitoxin
I8F59_RS13550	2728688..2730958	-	2271	WP_002361023.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
I8F59_RS13555	2731129..2731629	+	501	WP_002401100.1	cysteine hydrolase family protein	-
I8F59_RS13560	2732028..2732924	+	897	WP_002365354.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T183352 WP_021164441.1 NZ_CP065784:c2727782-2727681 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T183352 NZ_CP086920:c22442-22176 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Antitoxin

Nucleotide

• Length: 210 bp

>AT183352 NZ_CP065784:2727957-2728166 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCGGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin