Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1653863..1654472 Replicon chromosome
Accession NZ_CP065751
Organism Moraxella osloensis strain FDAARGOS_870

Toxin (Protein)


Gene name higB Uniprot ID A0A0X8K854
Locus tag I6G27_RS07290 Protein ID WP_062334682.1
Coordinates 1653863..1654201 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A120KQQ4
Locus tag I6G27_RS07295 Protein ID WP_062330561.1
Coordinates 1654191..1654472 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G27_RS07280 1649172..1650761 - 1590 WP_062330563.1 hypothetical protein -
I6G27_RS07285 1650790..1653639 - 2850 WP_197931493.1 hypothetical protein -
I6G27_RS07290 1653863..1654201 + 339 WP_062334682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G27_RS07295 1654191..1654472 + 282 WP_062330561.1 helix-turn-helix domain-containing protein Antitoxin
I6G27_RS07300 1654524..1654772 - 249 WP_062330559.1 hypothetical protein -
I6G27_RS07305 1654782..1657013 - 2232 WP_062330558.1 FtsW/RodA/SpoVE family cell cycle protein -
I6G27_RS07310 1657065..1657919 - 855 WP_062330556.1 RDD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-77)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12806.57 Da        Isoelectric Point: 9.8468

>T183324 WP_062334682.1 NZ_CP065751:1653863-1654201 [Moraxella osloensis]
MHFIETPLFTKQIKDLTDDDNYRDLQEDLIKNPQQGDLVQGTGGVRKTRWSSSSSTGKSGGMRIIYYYIEESGKFFMLLA
YPKSKKVTLSAAEKANLRKFTNAIKQVLHNEQ

Download         Length: 339 bp

>T183324 NZ_CP086895:39668-39943 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10366.84 Da        Isoelectric Point: 7.0111

>AT183324 WP_062330561.1 NZ_CP065751:1654191-1654472 [Moraxella osloensis]
MSNEFYDDLSLSLSQALSIAKGEAEPSRVFSYELPDIKAIRAKTGLTQAQFADKLNISSRTLQNWEQGTRHPTGATITLM
RLLEKKPELITLA

Download         Length: 282 bp

>AT183324 NZ_CP086895:39382-39675 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8K854

Antitoxin

Source ID Structure
AlphaFold DB A0A120KQQ4

References