Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5681857..5682674 Replicon chromosome
Accession NZ_CP065748
Organism Delftia lacustris strain FDAARGOS_890

Toxin (Protein)


Gene name yhaV Uniprot ID A0A7T2YQX9
Locus tag I6G47_RS26465 Protein ID WP_016452696.1
Coordinates 5681857..5682348 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A031I1Z5
Locus tag I6G47_RS26470 Protein ID WP_016452695.1
Coordinates 5682345..5682674 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G47_RS26435 5676983..5677468 + 486 WP_016452700.1 cobalamin biosynthesis protein -
I6G47_RS26440 5677465..5678343 + 879 WP_016452699.1 precorrin-4 C(11)-methyltransferase -
I6G47_RS26445 5678340..5679137 + 798 WP_016452698.1 precorrin-6A synthase (deacetylating) -
I6G47_RS26450 5679201..5679530 + 330 WP_013800515.1 DHCW motif cupin fold protein -
I6G47_RS26455 5679806..5681215 + 1410 WP_016452697.1 chloride channel protein -
I6G47_RS26460 5681330..5681842 + 513 WP_016448386.1 MgtC/SapB family protein -
I6G47_RS26465 5681857..5682348 - 492 WP_016452696.1 type II toxin-antitoxin system YhaV family toxin Toxin
I6G47_RS26470 5682345..5682674 - 330 WP_016452695.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
I6G47_RS26475 5682772..5685015 - 2244 WP_016452694.1 TonB-dependent receptor -
I6G47_RS26480 5685139..5685534 - 396 WP_016452693.1 hypothetical protein -
I6G47_RS26485 5685563..5686225 - 663 WP_016452692.1 pyridoxamine 5'-phosphate oxidase family protein -
I6G47_RS26490 5686296..5687129 + 834 WP_016448379.1 helix-turn-helix transcriptional regulator -
I6G47_RS26495 5687196..5687471 + 276 WP_016448378.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18813.43 Da        Isoelectric Point: 10.3998

>T183319 WP_016452696.1 NZ_CP065748:c5682348-5681857 [Delftia lacustris]
MSAVPPAPLRIHGWTVFMHPLFLAQLQALSQEVEGLKTKDPGGYTRKNATKRLAAIRKLAFDVIPQDPTRPDYRQGHTLG
EEHKHWFRARFFQQYRLFFRFHAPSKIIVFAWVNDEDTRRAYEGSDDAYRVFRKMLANGHPPGDWDSLLAQAKSPPPHSQ
PHA

Download         Length: 492 bp

>T183319 NZ_CP086888:92777-93043 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12036.45 Da        Isoelectric Point: 4.1858

>AT183319 WP_016452695.1 NZ_CP065748:c5682674-5682345 [Delftia lacustris]
MFSTLEAESTLTDRYQTTIPEAVRRALHLSKRDRIHYTILPGGEVVLSRADSAEDADPVLGQFLGFLAQDMAAHPERLQT
MDARLAQQIQALTEGIEVDLDAPLSADDE

Download         Length: 330 bp

>AT183319 NZ_CP086888:92529-92780 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T2YQX9

Antitoxin

Source ID Structure
AlphaFold DB A0A031I1Z5

References