Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 559013..559535 Replicon chromosome
Accession NZ_CP065729
Organism Macrococcus caseolyticus strain FDAARGOS_868

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag I6G25_RS02980 Protein ID WP_101140594.1
Coordinates 559263..559535 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag I6G25_RS02975 Protein ID WP_101140593.1
Coordinates 559013..559270 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G25_RS02955 554252..554701 - 450 WP_103214548.1 hypothetical protein -
I6G25_RS02960 554676..556289 - 1614 WP_101140590.1 ABC-F type ribosomal protection protein -
I6G25_RS02965 556697..557191 - 495 WP_157820952.1 cysteine hydrolase -
I6G25_RS02970 557710..558882 + 1173 WP_101140592.1 MFS transporter -
I6G25_RS02975 559013..559270 + 258 WP_101140593.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6G25_RS02980 559263..559535 + 273 WP_101140594.1 Txe/YoeB family addiction module toxin Toxin
I6G25_RS02985 559553..560320 - 768 WP_101140595.1 hypothetical protein -
I6G25_RS02990 560326..560811 - 486 WP_086038668.1 NUDIX domain-containing protein -
I6G25_RS02995 560843..561733 - 891 WP_012656930.1 phosphotransferase -
I6G25_RS03000 561743..562483 - 741 WP_101140596.1 hypothetical protein -
I6G25_RS03005 562566..563015 + 450 WP_101140597.1 GNAT family N-acetyltransferase -
I6G25_RS03010 563146..563532 - 387 WP_157819825.1 sporulation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10708.44 Da        Isoelectric Point: 9.7663

>T183288 WP_101140594.1 NZ_CP065729:559263-559535 [Macrococcus caseolyticus]
MPKKKILFYSSGFEDYTYWQSNDKTVLKRINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T183288 NZ_CP086856:c278126-277704 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.84 Da        Isoelectric Point: 4.0338

>AT183288 WP_101140593.1 NZ_CP065729:559013-559270 [Macrococcus caseolyticus]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTYNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT183288 NZ_CP086856:c278378-278130 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References