183262

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2010629..2011139 Replicon chromosome
Accession NZ_CP065711
Organism Staphylococcus carnosus strain FDAARGOS_883

Toxin (Protein)


Gene name yoeB Uniprot ID B9DKQ4
Locus tag I6G40_RS09730 Protein ID WP_012664284.1
Coordinates 2010870..2011139 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B9DKQ3
Locus tag I6G40_RS09725 Protein ID WP_012664283.1
Coordinates 2010629..2010877 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G40_RS09705 2006814..2007326 + 513 WP_012664280.1 YwhD family protein -
I6G40_RS09710 2007510..2008127 - 618 WP_012664281.1 LysE family transporter -
I6G40_RS09715 2008334..2008703 - 370 Protein_1864 fatty acid desaturase -
I6G40_RS09720 2008877..2010289 + 1413 WP_012664282.1 PLP-dependent aminotransferase family protein -
I6G40_RS09725 2010629..2010877 + 249 WP_012664283.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6G40_RS09730 2010870..2011139 + 270 WP_012664284.1 Txe/YoeB family addiction module toxin Toxin
I6G40_RS09735 2011626..2012816 + 1191 WP_012664285.1 amidohydrolase -
I6G40_RS09740 2012977..2013393 + 417 WP_012664286.1 DUF1934 family protein -
I6G40_RS09745 2013395..2015059 + 1665 WP_012664287.1 arginine--tRNA ligase -
I6G40_RS09750 2015191..2016093 + 903 WP_012664288.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10459.95 Da        Isoelectric Point: 10.0493

>T183262 WP_012664284.1 NZ_CP065711:2010870-2011139 [Staphylococcus carnosus]
MSKLNISFSPEAFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESIL
AASCKYHYQ

Download         Length: 270 bp

>T183262 NZ_CP086833:115046-115297 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9305.30 Da        Isoelectric Point: 4.2081

>AT183262 WP_012664283.1 NZ_CP065711:2010629-2010877 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Download         Length: 249 bp

>AT183262 NZ_CP086833:115294-115560 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9DKQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A380F8S2

References