Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 890667..891315 Replicon chromosome
Accession NZ_CP065707
Organism Streptococcus oralis strain FDAARGOS_885

Toxin (Protein)


Gene name higB Uniprot ID A0A7T2ZYA1
Locus tag I6G42_RS04345 Protein ID WP_038804830.1
Coordinates 890667..891032 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7T2ZYV9
Locus tag I6G42_RS04350 Protein ID WP_050562294.1
Coordinates 891022..891315 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G42_RS04320 885840..886877 + 1038 WP_000524474.1 hypothetical protein -
I6G42_RS04325 886870..888021 + 1152 WP_000042199.1 restriction endonuclease subunit S -
I6G42_RS04330 888075..889676 + 1602 WP_000450450.1 type I restriction-modification system subunit M -
I6G42_RS04335 889757..890161 + 405 WP_000438473.1 YbgA family protein -
I6G42_RS04340 890145..890510 + 366 WP_001241808.1 TIGR02328 family protein -
I6G42_RS04345 890667..891032 + 366 WP_038804830.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G42_RS04350 891022..891315 + 294 WP_050562294.1 helix-turn-helix transcriptional regulator Antitoxin
I6G42_RS04355 891668..893917 + 2250 WP_000108239.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
I6G42_RS04360 894012..894878 + 867 WP_038804832.1 methylenetetrahydrofolate reductase [NAD(P)H] -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14564.73 Da        Isoelectric Point: 9.9389

>T183255 WP_038804830.1 NZ_CP065707:890667-891032 [Streptococcus oralis]
VHTIYFYKDKNGNEPVLDYMRQLARKKSKDSRIKLNKLNDYIELLSQHGTRTGEPYIKHLEDEIWELRPLKDRILFVAWV
DGSFVLLHHFVKKTQKTPRREIDKSKRELKDIKERGLSDEE

Download         Length: 366 bp

>T183255 NZ_CP086826:c119625-119299 [Pseudosulfitobacter pseudonitzschiae]
GTGAGGCGTGGTGAGCTGGTGACGGTCGCCCTTCAGGGCGACCACGGCAAGCCGCGTCCCGCGCTTGTGATCCAATCCGA
CCGGTTTCCGGACACCGCCACCACGACCGTCCTTCTGGTTACATCCACCTTGGTGGATGCGCCGTTGATTCGGCTGACGG
TCGAACCCTCTGCGGAGAACGGGTTGCGTATGCGATCACAGATCATGATCGACAAAGCCGTGACAGTTCGAACGGACAAG
CTGGGGAAAGCTTTCGGTCAGCTGGACGATACCGCCATGATCGAGGTGAACCGGGCACTAGCACTGTTTTTAGGAGTGGC
GGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10793.46 Da        Isoelectric Point: 5.1991

>AT183255 WP_050562294.1 NZ_CP065707:891022-891315 [Streptococcus oralis]
MKNSAIGSNWKDIRTELFTKEEILESDMRVAIMSELIEARHEQGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKN

Download         Length: 294 bp

>AT183255 NZ_CP086826:c119840-119622 [Pseudosulfitobacter pseudonitzschiae]
ATGCCAACCTCTGTTTCTCACCGTGTCCAGAAGCGTCGCGATGCCTTGCGTGCCGCTGGTTTGCGCCCCGTCCAGATTTG
GGTGCCGGATACCCGCCGCCCCGGTTTCGAGGCTGAGTGCCGCCGCCAGGCTGCAATTGTAGCCAAGGCCGATCGCGCAG
ATGATACTCTGAACGATTTCCTGGATGCCTCCCTGGTCGATGTGGATGACTGGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T2ZYA1

Antitoxin

Source ID Structure
AlphaFold DB A0A7T2ZYV9

References