Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 603222..603870 Replicon chromosome
Accession NZ_CP065706
Organism Streptococcus oralis strain FDAARGOS_886

Toxin (Protein)


Gene name higB Uniprot ID A0A7T2ZP45
Locus tag I6G43_RS02815 Protein ID WP_038806358.1
Coordinates 603222..603587 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7T3DUD8
Locus tag I6G43_RS02820 Protein ID WP_050562754.1
Coordinates 603577..603870 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G43_RS02790 598823..599737 + 915 WP_038806362.1 haloacid dehalogenase-like hydrolase -
I6G43_RS02795 599809..600564 + 756 WP_038806360.1 hypothetical protein -
I6G43_RS02800 600609..602210 + 1602 WP_038806474.1 type I restriction-modification system subunit M -
I6G43_RS02805 602314..602717 + 404 Protein_518 YbgA family protein -
I6G43_RS02810 602701..603066 + 366 WP_038806359.1 TIGR02328 family protein -
I6G43_RS02815 603222..603587 + 366 WP_038806358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G43_RS02820 603577..603870 + 294 WP_050562754.1 helix-turn-helix transcriptional regulator Antitoxin
I6G43_RS02825 604131..606380 + 2250 WP_038806357.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
I6G43_RS02830 606444..607310 + 867 WP_038806356.1 methylenetetrahydrofolate reductase [NAD(P)H] -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14591.76 Da        Isoelectric Point: 9.7913

>T183253 WP_038806358.1 NZ_CP065706:603222-603587 [Streptococcus oralis]
VHTIYFYKDKNGNEPVLDYMRELARKKSKDSRIKLNKLNDYIELLSQHGTRTGEPYIKHLEDEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIEKAKRELKDIKERGVSDEE

Download         Length: 366 bp

>T183253 NZ_CP086824:c2526908-2526654 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10757.47 Da        Isoelectric Point: 6.3903

>AT183253 WP_050562754.1 NZ_CP065706:603577-603870 [Streptococcus oralis]
MKNSAIGSNWKDVRSELFTKEEILESDMRVAIMSELIEARREKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKS

Download         Length: 294 bp

>AT183253 NZ_CP086824:c2526657-2526328 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T2ZP45

Antitoxin

Source ID Structure
AlphaFold DB A0A7T3DUD8

References