Detailed information of TA system TA183249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2748676..2749322
• Replicon: chromosome
• Accession: NZ_CP065700
• Organism: Atlantibacter hermannii strain FDAARGOS_888

Toxin (Protein)

• Gene name: higB
• Uniprot ID: H5UXB4
• Locus tag: I6G45_RS12985
• Protein ID: WP_002463190.1
• Coordinates: 2748969..2749322 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: H5UXB3
• Locus tag: I6G45_RS12980
• Protein ID: WP_002463188.1
• Coordinates: 2748676..2748972 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G45_RS12970	2746315..2747169	-	855	WP_002463186.1	DNA-3-methyladenine glycosylase 2	-
I6G45_RS12975	2747301..2748653	+	1353	WP_002463187.1	molecular chaperone	-
I6G45_RS12980	2748676..2748972	-	297	WP_002463188.1	helix-turn-helix transcriptional regulator	Antitoxin
I6G45_RS12985	2748969..2749322	-	354	WP_002463190.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G45_RS12990	2749550..2750803	+	1254	WP_002463191.1	MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit	-
I6G45_RS12995	2750803..2753925	+	3123	WP_002463192.1	MdtB/MuxB family multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-99)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-88)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13569.72 Da
• Isoelectric Point: 10.0566

>T183249 WP_002463190.1 NZ_CP065700:c2749322-2748969 [Atlantibacter hermannii]
MTWTVVLTPEFEQWFDKQEAGLQDRINMMITLLEISGPNLGRPHVDTLVGSRYPNMKELRIQYAGEPWRVGFAFNHRQQA
VLLYGGQKTGKKRFYTLLIAQVDAIFARDLARKKETL

Nucleotide

• Length: 354 bp

>T183249 NZ_CP086820:c55972-55706 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11034.79 Da
• Isoelectric Point: 8.5172

>AT183249 WP_002463188.1 NZ_CP065700:c2748972-2748676 [Atlantibacter hermannii]
MKTFQEKLAEYSPERRAKIERMAEAFAAENGLPTLREMRAMSQQELAERLGVTQPAVAAMERRGEDIKVSTLKRYAEALG
GELKITIELPEGRKVISL

Nucleotide

• Length: 297 bp

>AT183249 NZ_CP086820:c56220-55969 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Structures

Toxin

• AlphaFold DB: H5UXB4

Antitoxin

• AlphaFold DB: H5UXB3