Detailed information of TA system TA183240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2095928..2096637
• Replicon: chromosome
• Accession: NZ_CP065700
• Organism: Atlantibacter hermannii strain FDAARGOS_888

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: H5V274
• Locus tag: I6G45_RS09705
• Protein ID: WP_002435659.1
• Coordinates: 2095928..2096233 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: H5V273
• Locus tag: I6G45_RS09710
• Protein ID: WP_002435658.1
• Coordinates: 2096233..2096637 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G45_RS09680	2091768..2092202	+	435	WP_040459814.1	multiple antibiotic resistance transcriptional regulator MarR	-
I6G45_RS09685	2092220..2092594	+	375	WP_002435664.1	MDR efflux pump AcrAB transcriptional activator MarA	-
I6G45_RS09690	2092627..2092836	+	210	WP_040459853.1	multiple antibiotic resistance regulatory protein MarB	-
I6G45_RS09695	2093560..2094456	-	897	WP_002435661.1	O-acetylserine/cysteine exporter	-
I6G45_RS09700	2094655..2095848	+	1194	WP_002435660.1	efflux MFS transporter YdeE	-
I6G45_RS09705	2095928..2096233	+	306	WP_002435659.1	type II toxin-antitoxin system MqsR family toxin	Toxin
I6G45_RS09710	2096233..2096637	+	405	WP_002435658.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
I6G45_RS09715	2096671..2097369	-	699	WP_002435657.1	urea ABC transporter ATP-binding subunit UrtE	-
I6G45_RS09720	2097379..2098176	-	798	WP_040459852.1	urea ABC transporter ATP-binding protein UrtD	-
I6G45_RS09725	2098176..2099249	-	1074	WP_040459851.1	urea ABC transporter permease subunit UrtC	-
I6G45_RS09730	2099249..2100823	-	1575	WP_002435654.1	urea ABC transporter permease subunit UrtB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-100)

Antitoxin

• Antitoxin MqsA (4-131)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11652.75 Da
• Isoelectric Point: 9.4481

>T183240 WP_002435659.1 NZ_CP065700:2095928-2096233 [Atlantibacter hermannii]
MRKGTPNVPLSVVKEMVRSGKVKTTFTATQGALELGFPAPVLPLMCKVVLLLDQSHFYKSMTAYHDETIWHDVYRTRFDE
RHIYLKLIVKDDVLIVSFKEL

Nucleotide

• Length: 306 bp

>T183240 NZ_CP086811:240884-241210 [Pseudosulfitobacter pseudonitzschiae]
GTGAGGCGTGGTGAGCTGGTGACGGTCGCCCTTCAGGGCGACCACGGCAAGCCGCGTCCCGCGCTTGTGATCCAATCCGA
CCGGTTTCCGGACACCGCCACCACGACCGTCCTTCTGGTTACATCCACCTTGGTGGATGCGCCGTTGATTCGGCTGACGG
TCGAACCCTCTGCGGAGAACGGGTTGCGTATGCGATCACAGATCATGATCGACAAAGCCGTGACAGTTCGAACGGACAAG
CTGGGGAAAGCTTTCGGTCAGCTGGACGATACCGCCATGATCGAGGTGAACCGGGCACTAGCACTGTTTTTAGGAGTGGC
GGGGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14921.97 Da
• Isoelectric Point: 7.6663

>AT183240 WP_002435658.1 NZ_CP065700:2096233-2096637 [Atlantibacter hermannii]
MKTCPVCGGGHLTHESRDLPYEYKGSKTTLRGIVGEYCNSCGEIIFTPEESNAFSAQASAFRTAVNAESFDPTLFTRVRK
NLRIDQQQAGMLFGGGVNAFSRYETGKTTPPIAVVKLFKMFDKFPELFEEYKSL

Nucleotide

• Length: 405 bp

>AT183240 NZ_CP086811:240669-240887 [Pseudosulfitobacter pseudonitzschiae]
ATGCCAACCTCTGTTTCTCACCGTGTCCAGAAGCGTCGCGATGCCTTGCGTGCCGCTGGTTTGCGCCCCGTCCAGATTTG
GGTGCCGGATACCCGCCGCCCCGGTTTCGAGGCTGAGTGCCGCCGCCAGGCTGCAATTGTAGCCAAGGCCGATCGCGCAG
ATGATACTCTGAACGATTTCCTGGATGCCTCCCTGGTCGATGTGGATGACTGGGAGTGA

Structures

Toxin

• AlphaFold DB: H5V274

Antitoxin

• AlphaFold DB: H5V273