183235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3288134..3288787 Replicon chromosome
Accession NZ_CP065699
Organism Serratia plymuthica strain FDAARGOS_889

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6G46_RS15585 Protein ID WP_064798643.1
Coordinates 3288437..3288787 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6G46_RS15580 Protein ID WP_013811356.1
Coordinates 3288134..3288433 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G46_RS15555 3283374..3283925 + 552 WP_006323400.1 NAD(P)H-dependent oxidoreductase -
I6G46_RS15560 3283972..3284229 + 258 WP_020438390.1 acyl carrier protein -
I6G46_RS15565 3284244..3285467 + 1224 WP_006323398.1 cytochrome P450 -
I6G46_RS15570 3285467..3286735 + 1269 WP_020438388.1 multidrug effflux MFS transporter -
I6G46_RS15575 3287021..3288097 + 1077 WP_197912188.1 YncE family protein -
I6G46_RS15580 3288134..3288433 - 300 WP_013811356.1 helix-turn-helix transcriptional regulator Antitoxin
I6G46_RS15585 3288437..3288787 - 351 WP_064798643.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G46_RS15590 3288953..3289267 - 315 WP_064798642.1 hypothetical protein -
I6G46_RS15595 3289523..3290902 + 1380 WP_037432122.1 glutamine synthetase family protein -
I6G46_RS15600 3290960..3291499 + 540 WP_037432120.1 GNAT family N-acetyltransferase -
I6G46_RS15605 3291514..3292215 + 702 WP_064799538.1 trehalose-6-phosphate synthase -
I6G46_RS15610 3292217..3293308 - 1092 WP_062791015.1 dimethyl sulfone monooxygenase SfnG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13514.59 Da        Isoelectric Point: 7.8898

>T183235 WP_064798643.1 NZ_CP065699:c3288787-3288437 [Serratia plymuthica]
MWTVITTEEFDRWFAVQDELTQEKVLAALVLLERSDPNLSRPFVDSLRGSQHPNMKELRVQHKGRPIRAFFAFDSLRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFKE

Download         Length: 351 bp

>T183235 NZ_CP086808:c89797-89534 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11183.85 Da        Isoelectric Point: 5.1667

>AT183235 WP_013811356.1 NZ_CP065699:c3288433-3288134 [Serratia plymuthica]
MGTLKDMLASRTPESLQRIEEMAQEMWLEARLYQLREALNISQQELANNLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDVELPDGKHVGFRV

Download         Length: 300 bp

>AT183235 NZ_CP086808:c89547-89332 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References