Detailed information of TA system TA183206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2576759..2577419
• Replicon: chromosome
• Accession: NZ_CP065693
• Organism: Enterobacter asburiae strain FDAARGOS_892

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A376FK36
• Locus tag: I6G49_RS12840
• Protein ID: WP_029741461.1
• Coordinates: 2576759..2577112 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6G49_RS12845
• Protein ID: WP_054830246.1
• Coordinates: 2577117..2577419 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G49_RS12820	2572901..2573818	+	918	WP_054830244.1	nitrogen assimilation transcriptional regulator NAC	-
I6G49_RS12825	2573915..2574865	+	951	WP_023336219.1	HTH-type transcriptional regulator Cbl	-
I6G49_RS12830	2574909..2575517	-	609	WP_081051431.1	glutathione S-transferase family protein	-
I6G49_RS12835	2575688..2576581	+	894	WP_059347000.1	LysR family transcriptional regulator	-
I6G49_RS12840	2576759..2577112	+	354	WP_029741461.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G49_RS12845	2577117..2577419	+	303	WP_054830246.1	XRE family transcriptional regulator	Antitoxin
I6G49_RS12850	2577495..2578415	-	921	WP_059346999.1	LysR family transcriptional regulator	-
I6G49_RS12855	2578557..2578958	+	402	WP_054830247.1	RidA family protein	-
I6G49_RS12865	2579253..2581442	-	2190	WP_059346998.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (25-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13531.36 Da
• Isoelectric Point: 9.0310

>T183206 WP_029741461.1 NZ_CP065693:2576759-2577112 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLEDTDRASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERE

Nucleotide

• Length: 354 bp

>T183206 NZ_CP086776:23268-23534 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11024.80 Da
• Isoelectric Point: 5.7316

>AT183206 WP_054830246.1 NZ_CP065693:2577117-2577419 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKAGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT183206 NZ_CP086776:23020-23271 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Structures

Toxin

• AlphaFold DB: A0A376FK36