Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 20763..21302 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP065692 | ||
| Organism | Enterobacter asburiae strain FDAARGOS_892 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | J2DZM3 |
| Locus tag | I6G49_RS00135 | Protein ID | WP_004150484.1 |
| Coordinates | 20763..21038 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A5H6MLU0 |
| Locus tag | I6G49_RS00140 | Protein ID | WP_001570852.1 |
| Coordinates | 21042..21302 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6G49_RS00085 | 16245..16439 | - | 195 | WP_059347882.1 | hypothetical protein | - |
| I6G49_RS00090 | 16456..16995 | - | 540 | WP_032445848.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| I6G49_RS00095 | 17011..17568 | - | 558 | WP_059347883.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| I6G49_RS00100 | 17571..17882 | - | 312 | WP_048242340.1 | hypothetical protein | - |
| I6G49_RS00105 | 18018..18311 | - | 294 | WP_059347885.1 | hypothetical protein | - |
| I6G49_RS00110 | 18550..18861 | - | 312 | WP_054829977.1 | hypothetical protein | - |
| I6G49_RS00115 | 18858..19067 | - | 210 | WP_054829978.1 | hypothetical protein | - |
| I6G49_RS00120 | 19078..19605 | - | 528 | WP_059347886.1 | ankyrin repeat domain-containing protein | - |
| I6G49_RS00125 | 19938..20594 | + | 657 | WP_059347887.1 | hypothetical protein | - |
| I6G49_RS00130 | 20606..20812 | - | 207 | WP_162184628.1 | hypothetical protein | - |
| I6G49_RS00135 | 20763..21038 | - | 276 | WP_004150484.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| I6G49_RS00140 | 21042..21302 | - | 261 | WP_001570852.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| I6G49_RS00145 | 23302..23886 | - | 585 | WP_048242305.1 | hypothetical protein | - |
| I6G49_RS00150 | 23898..24125 | - | 228 | WP_001569532.1 | hypothetical protein | - |
| I6G49_RS00155 | 24125..24601 | - | 477 | WP_059347865.1 | hypothetical protein | - |
| I6G49_RS00160 | 24715..24990 | - | 276 | WP_060615702.1 | hypothetical protein | - |
| I6G49_RS00165 | 24981..25286 | - | 306 | WP_128334256.1 | hypothetical protein | - |
| I6G49_RS00170 | 25332..25718 | - | 387 | WP_048242309.1 | hypothetical protein | - |
| I6G49_RS00175 | 25823..26125 | - | 303 | WP_048242310.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..44679 | 44679 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10750.40 Da Isoelectric Point: 9.6586
>T183200 WP_004150484.1 NZ_CP065692:c21038-20763 [Enterobacter asburiae]
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF
Download Length: 276 bp
>T183200 NZ_CP086772:c70680-70405 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9239.63 Da Isoelectric Point: 5.0336
>AT183200 WP_001570852.1 NZ_CP065692:c21302-21042 [Enterobacter asburiae]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI
Download Length: 261 bp
>AT183200 NZ_CP086772:c70966-70673 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J2DZM3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H6MLU0 |