Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2874985..2875640 Replicon chromosome
Accession NZ_CP065683
Organism Burkholderia oklahomensis strain FDAARGOS_900

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6G57_RS13310 Protein ID WP_010105746.1
Coordinates 2875296..2875640 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6G57_RS13305 Protein ID WP_010105748.1
Coordinates 2874985..2875299 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G57_RS13285 2871127..2872320 - 1194 WP_010105766.1 pyridoxal phosphate-dependent aminotransferase -
I6G57_RS13290 2872382..2872819 - 438 WP_010105764.1 transcription antitermination factor NusB -
I6G57_RS13295 2872816..2873334 - 519 WP_010105762.1 6,7-dimethyl-8-ribityllumazine synthase -
I6G57_RS13300 2873415..2874551 - 1137 WP_010105760.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
I6G57_RS13305 2874985..2875299 - 315 WP_010105748.1 transcriptional regulator Antitoxin
I6G57_RS13310 2875296..2875640 - 345 WP_010105746.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G57_RS13315 2875801..2876301 + 501 WP_038800987.1 hypothetical protein -
I6G57_RS13320 2876455..2877084 - 630 WP_010105743.1 riboflavin synthase -
I6G57_RS13325 2877099..2878235 - 1137 WP_038800986.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
I6G57_RS13330 2878264..2879547 - 1284 WP_010105739.1 glutamate-1-semialdehyde 2,1-aminomutase -
I6G57_RS13335 2879842..2880300 - 459 WP_010105738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.1937

>T183171 WP_010105746.1 NZ_CP065683:c2875640-2875296 [Burkholderia oklahomensis]
MEATFIELPTFSRERENYLADDEYAVLQKELLANPEAGDMIKGAGGLRKLRFADKRRQKGKRGGLRVIYYYWVSGYQFWL
FTLYDKDEMADLSSDERKAFAKLLEREVTIRSKQ

Download         Length: 345 bp

>T183171 NZ_CP086728:c993901-993644 [Streptococcus parasuis]
ATGAAGACTTGTTATAAACTCGTACCAACCAGTCGTTTTATTAAACAGTTGAAAAAGCTGGATAAATTTACCCAAAAGCA
GATTACCAACTACCTGTCCAGTCATGTGACCGACAACCCCAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGTATTGAAGATGACAAAGTGACAGTTACAAGTCTAAAAATG
AGAAATGGAAGCATATAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11560.41 Da        Isoelectric Point: 10.3388

>AT183171 WP_010105748.1 NZ_CP065683:c2875299-2874985 [Burkholderia oklahomensis]
MKKRNLFAELTEGLDALAAEREGKITLRKIKADVPDALEVSPAEIKAVREASHASQAVMARSLRINVRTYQNWEQGKAKP
NAQAATLIRLVAKHPETLQMLETL

Download         Length: 315 bp

>AT183171 NZ_CP086728:c994136-993885 [Streptococcus parasuis]
ATGGCAGCTATTACTTTAAAGGTTTCTGAGCAAGACAAGCTATTTATGCAGGCTATGGCAAAGTTTGAAGGCGTGAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAGTATGATGCGCGTGTGGCTGATATTGCTCTGGCAG
AATACCAAGAAGACTTGGCAAACGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGATTGACGAATGAA
GACTTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References