Detailed information of TA system TA183170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 2013640..2014297
• Replicon: chromosome
• Accession: NZ_CP065683
• Organism: Burkholderia oklahomensis strain FDAARGOS_900

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6G57_RS09220
• Protein ID: WP_010111813.1
• Coordinates: 2013640..2013972 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6G57_RS09225
• Protein ID: WP_010111811.1
• Coordinates: 2013980..2014297 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G57_RS09200	2009283..2010647	+	1365	WP_038802797.1	type II secretory pathway protein	-
I6G57_RS09205	2010957..2011433	+	477	WP_038802796.1	hypothetical protein	-
I6G57_RS09210	2011884..2012663	+	780	WP_038801760.1	hypothetical protein	-
I6G57_RS09215	2013011..2013598	+	588	WP_038801761.1	site-specific integrase	-
I6G57_RS09220	2013640..2013972	+	333	WP_010111813.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G57_RS09225	2013980..2014297	+	318	WP_010111811.1	helix-turn-helix domain-containing protein	Antitoxin
I6G57_RS09230	2014497..2014802	+	306	WP_081464427.1	DUF3892 domain-containing protein	-
I6G57_RS09240	2015084..2016406	-	1323	WP_038802795.1	IS5 family transposase	-
I6G57_RS09245	2016555..2017577	-	1023	WP_081956034.1	site-specific integrase	-
I6G57_RS09250	2017601..2018629	+	1029	WP_038802586.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2004540..2036836	32296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-97)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12863.95 Da
• Isoelectric Point: 10.3619

>T183170 WP_010111813.1 NZ_CP065683:2013640-2013972 [Burkholderia oklahomensis]
MKFDWTIVYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPQHELRIAQARLREVRNG

Nucleotide

• Length: 333 bp

>T183170 NZ_CP086728:160436-160606 [Streptococcus parasuis]
TTGAGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCTTCATCTGACCCGAGGCTACGTCATTGGAAAAGA
CTACATTGCTCTCTATCGCGTAGTGAAAAATGAACTTCGAGTTGTTCACCTTTTTGCGACCAAGAGTGATTATGTTAAGT
TGTTGAAGTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11235.76 Da
• Isoelectric Point: 10.2231

>AT183170 WP_010111811.1 NZ_CP065683:2013980-2014297 [Burkholderia oklahomensis]
VKRARAEGFNPVPHTADDTARLLAGRNVKAAYDALEDEYTALRAILSARREAGLTQAQIAERMGTTASAVSRLEASLSSE
KHSPSFATLRKYAAACGKKLVISFA

Nucleotide

• Length: 318 bp

>AT183170 NZ_CP086728:160212-160340 [Streptococcus parasuis]
ATGAGTGAATTGGAAACAGGCAAGGAAGTATTTGCTATGAACGAGCTGGATTTGACTGCTAGCTTCAATCTAATTTTACA
AAACATTGCTGTAAAAAATGAGTTGCTAATTCTGACAGAAGAAGAGTAG