Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2731503..2732187 Replicon chromosome
Accession NZ_CP065682
Organism Brevibacterium casei strain FDAARGOS_902

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag I6G59_RS12345 Protein ID WP_095375611.1
Coordinates 2731834..2732187 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag I6G59_RS12340 Protein ID WP_095375612.1
Coordinates 2731503..2731832 (-) Length 110 a.a.

Genomic Context

I6G59_RS12315I6G59_RS12320I6G59_RS12325I6G59_RS12355I6G59_RS12360I6G59_RS12365I6G59_RS12370I6G59_RS12375I6G59_RS12310I6G59_RS12330I6G59_RS12335I6G59_RS12340I6G59_RS12345I6G59_RS12350
Location: 2728500..2728868 (369 bp)
Type: Others
Protein ID: WP_095376837.1
Location: 2728872..2729444 (573 bp)
Type: Others
Protein ID: WP_095376836.1
Location: 2729696..2730031 (336 bp)
Type: Others
Protein ID: WP_176472431.1
Location: 2733496..2734440 (945 bp)
Type: Others
Protein ID: WP_095375619.1
Location: 2734534..2735010 (477 bp)
Type: Others
Protein ID: WP_095375608.1
Location: 2735007..2736218 (1212 bp)
Type: Others
Protein ID: WP_095375607.1
Location: 2736363..2736692 (330 bp)
Type: Others
Protein ID: WP_009375656.1
Location: 2736712..2737125 (414 bp)
Type: Others
Protein ID: WP_095375606.1
Location: 2727178..2728188 (1011 bp)
Type: Others
Protein ID: WP_095376838.1
Location: 2730043..2730351 (309 bp)
Type: Others
Protein ID: WP_095375620.1
Location: 2730528..2731160 (633 bp)
Type: Others
Protein ID: WP_141236326.1
Location: 2731503..2731832 (330 bp)
Type: Antitoxin
Protein ID: WP_095375612.1
Location: 2731834..2732187 (354 bp)
Type: Toxin
Protein ID: WP_095375611.1
Location: 2732385..2732870 (486 bp)
Type: Others
Protein ID: WP_176472430.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G59_RS123102727178..2728188-1011WP_095376838.1nucleotidyltransferase-
I6G59_RS123152728500..2728868+369WP_095376837.1transcriptional regulator-
I6G59_RS123202728872..2729444+573WP_095376836.1ImmA/IrrE family metallo-endopeptidase-
I6G59_RS123252729696..2730031+336WP_176472431.1hypothetical protein-
I6G59_RS123302730043..2730351-309WP_095375620.1helix-turn-helix domain-containing protein-
I6G59_RS123352730528..2731160-633WP_141236326.1hypothetical protein-
I6G59_RS123402731503..2731832-330WP_095375612.1XRE family transcriptional regulatorAntitoxin
I6G59_RS123452731834..2732187-354WP_095375611.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6G59_RS123502732385..2732870-486WP_176472430.1hypothetical protein-
I6G59_RS123552733496..2734440+945WP_095375619.1hypothetical protein-
I6G59_RS123602734534..2735010+477WP_095375608.1ion transporter-
I6G59_RS123652735007..2736218+1212WP_095375607.1chloride channel protein-
I6G59_RS123702736363..2736692+330WP_009375656.1nuclear transport factor 2 family protein-
I6G59_RS123752736712..2737125+414WP_095375606.1RidA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2723037..273316110124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-93)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13609.28 Da        Isoelectric Point: 4.8212

>T183169 WP_095375611.1 NZ_CP065682:c2732187-2731834 [Brevibacterium casei]
MSWDVRLWEDVESWVLELDDETYNLLAAAITRLESEGPTLGRPTADRIKGSRHHNMKELRPGSAGRSEIRVLFAFDPKRR
AILLIAGDKAGRWKQWYAQNIPIADDRFDEWLTNEEE

Download         Length: 354 bp

>T183169 NZ_CP086726:3075101-3075964 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11972.59 Da        Isoelectric Point: 8.5542

>AT183169 WP_095375612.1 NZ_CP065682:c2731832-2731503 [Brevibacterium casei]
MSTKTKTTAWSDVRAKRPVNEAAVAEHVARMEAEERAYRLREIREEQGVTQKQLAERMALTQPTISALEAGELDRSGLAT
LKSYVEALGGTIEVTATFGNRKLVLSPQG

Download         Length: 330 bp

>AT183169 NZ_CP086726:3074827-3075099 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References