Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2355229..2355799 Replicon chromosome
Accession NZ_CP065682
Organism Brevibacterium casei strain FDAARGOS_902

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6G59_RS10485 Protein ID WP_101624910.1
Coordinates 2355229..2355510 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6G59_RS10490 Protein ID WP_095375736.1
Coordinates 2355497..2355799 (+) Length 101 a.a.

Genomic Context

I6G59_RS10485I6G59_RS10490I6G59_RS10495I6G59_RS10500I6G59_RS10505I6G59_RS10520I6G59_RS10465I6G59_RS10470I6G59_RS10475I6G59_RS10480I6G59_RS10510I6G59_RS10515
Location: 2355229..2355510 (282 bp)
Type: Toxin
Protein ID: WP_101624910.1
Location: 2355497..2355799 (303 bp)
Type: Antitoxin
Protein ID: WP_095375736.1
Location: 2355803..2356357 (555 bp)
Type: Others
Protein ID: WP_197931745.1
Location: 2356421..2356927 (507 bp)
Type: Others
Protein ID: WP_193338759.1
Location: 2357083..2357460 (378 bp)
Type: Others
Protein ID: WP_101624913.1
Location: 2359475..2360650 (1176 bp)
Type: Others
Protein ID: WP_040341108.1
Location: 2350797..2351120 (324 bp)
Type: Others
Protein ID: WP_125106242.1
Location: 2351138..2351443 (306 bp)
Type: Others
Protein ID: WP_094394865.1
Location: 2351454..2354462 (3009 bp)
Type: Others
Protein ID: WP_197932413.1
Location: 2354534..2354839 (306 bp)
Type: Others
Protein ID: WP_009374917.1
Location: 2357521..2357790 (270 bp)
Type: Others
Protein ID: WP_095375740.1
Location: 2357949..2359094 (1146 bp)
Type: Others
Protein ID: WP_009374936.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G59_RS104652350797..2351120-324WP_125106242.1hypothetical protein-
I6G59_RS104702351138..2351443-306WP_094394865.1DCL family protein-
I6G59_RS104752351454..2354462-3009WP_197932413.1DNA-directed DNA polymerase-
I6G59_RS104802354534..2354839-306WP_009374917.1helix-turn-helix domain-containing protein-
I6G59_RS104852355229..2355510+282WP_101624910.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6G59_RS104902355497..2355799+303WP_095375736.1HigA family addiction module antidote proteinAntitoxin
I6G59_RS104952355803..2356357+555WP_197931745.1GNAT family N-acetyltransferase-
I6G59_RS105002356421..2356927+507WP_193338759.1hypothetical protein-
I6G59_RS105052357083..2357460+378WP_101624913.1hypothetical protein-
I6G59_RS105102357521..2357790-270WP_095375740.1DUF3263 domain-containing protein-
I6G59_RS105152357949..2359094-1146WP_009374936.1glycerol dehydrogenase-
I6G59_RS105202359475..2360650+1176WP_040341108.1low temperature requirement protein A-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10872.34 Da        Isoelectric Point: 9.1995

>T183168 WP_101624910.1 NZ_CP065682:2355229-2355510 [Brevibacterium casei]
VIRSFGSKETERLWRRERVRSIDPRIHRVALRKLRQVGSAEVLEDLSVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T183168 NZ_CP086726:c2719601-2719257 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11059.61 Da        Isoelectric Point: 5.1100

>AT183168 WP_095375736.1 NZ_CP065682:2355497-2355799 [Brevibacterium casei]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSPEFWINLQSHYEL
DRAEDAAGEQIAAITPLRVA

Download         Length: 303 bp

>AT183168 NZ_CP086726:c2719950-2719618 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References