Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 4595966..4596589 Replicon chromosome
Accession NZ_CP065668
Organism Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6G66_RS21610 Protein ID WP_197954472.1
Coordinates 4595966..4596247 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6G66_RS21615 Protein ID WP_013800141.1
Coordinates 4596290..4596589 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G66_RS21585 4591200..4592063 + 864 WP_183021245.1 branched-chain amino acid ABC transporter permease -
I6G66_RS21590 4592064..4593038 + 975 WP_012202200.1 branched-chain amino acid ABC transporter permease -
I6G66_RS21595 4593025..4593789 + 765 WP_013800137.1 ABC transporter ATP-binding protein -
I6G66_RS21600 4593776..4594483 + 708 WP_183021247.1 ABC transporter ATP-binding protein -
I6G66_RS21605 4594661..4595836 + 1176 WP_183021248.1 ABC transporter substrate-binding protein -
I6G66_RS21610 4595966..4596247 + 282 WP_197954472.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G66_RS21615 4596290..4596589 + 300 WP_013800141.1 HigA family addiction module antidote protein Antitoxin
I6G66_RS21620 4596682..4597455 - 774 WP_183021249.1 SDR family oxidoreductase -
I6G66_RS21625 4597581..4598387 - 807 WP_197954473.1 IclR family transcriptional regulator -
I6G66_RS21630 4598432..4599205 - 774 WP_183021251.1 ferredoxin--NADP reductase -
I6G66_RS21635 4599466..4600401 - 936 WP_197954474.1 LysR family transcriptional regulator -
I6G66_RS21640 4600495..4601286 + 792 WP_097204607.1 SDR family oxidoreductase -
I6G66_RS21645 4601304..4601585 - 282 WP_183021253.1 DUF3325 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11095.76 Da        Isoelectric Point: 10.1036

>T183143 WP_197954472.1 NZ_CP065668:4595966-4596247 [Delftia acidovorans]
MTIRSFKCPDTEQLFQQRRVRRWSSIEVVALRKLRMLHAAHVLQDLRVPPGNRLEALHGDRKGQHSIRINDQWRVCFVWT
HEGPSELEIVDYH

Download         Length: 282 bp

>T183143 NZ_CP086681:22303-22683 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10990.57 Da        Isoelectric Point: 4.5183

>AT183143 WP_013800141.1 NZ_CP065668:4596290-4596589 [Delftia acidovorans]
MNKPLNLPTPGEILATEFLEPMGLTQYRLAQAIHVPQTRIAAIVKNGRSITADTALRLARFFGTSVEFWMNLQSQYDADI
AREAIGDDLESIEPFALQA

Download         Length: 300 bp

>AT183143 NZ_CP086681:22082-22303 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References