183134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1514991..1515507 Replicon chromosome
Accession NZ_CP065662
Organism Aerococcus urinae strain FDAARGOS_911

Toxin (Protein)


Gene name yafQ Uniprot ID A0A109RE66
Locus tag I6G68_RS06945 Protein ID WP_060778045.1
Coordinates 1514991..1515263 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A109REE1
Locus tag I6G68_RS06950 Protein ID WP_060778044.1
Coordinates 1515256..1515507 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G68_RS06930 1511201..1513768 - 2568 WP_174519276.1 DNA mismatch repair protein MutS -
I6G68_RS06935 1513917..1514543 + 627 WP_060778046.1 phosphoglycerate mutase family protein -
I6G68_RS06945 1514991..1515263 - 273 WP_060778045.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6G68_RS06950 1515256..1515507 - 252 WP_060778044.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6G68_RS06955 1515711..1516127 - 417 WP_060778043.1 GTP pyrophosphokinase -
I6G68_RS06960 1516111..1516305 - 195 WP_060778042.1 hypothetical protein -
I6G68_RS06965 1517063..1517545 - 483 WP_060778041.1 hypothetical protein -
I6G68_RS06970 1517590..1518195 - 606 WP_060778040.1 hypothetical protein -
I6G68_RS06975 1518216..1518581 - 366 WP_060778039.1 hypothetical protein -
I6G68_RS06980 1518603..1519037 - 435 WP_060778038.1 DUF1492 domain-containing protein -
I6G68_RS06985 1519195..1519464 - 270 WP_060778037.1 hypothetical protein -
I6G68_RS06990 1519479..1519721 - 243 WP_060778036.1 hypothetical protein -
I6G68_RS06995 1519733..1519975 - 243 WP_060778035.1 hypothetical protein -
I6G68_RS07000 1519986..1520234 - 249 WP_060778034.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10744.52 Da        Isoelectric Point: 9.8078

>T183134 WP_060778045.1 NZ_CP065662:c1515263-1514991 [Aerococcus urinae]
MNKIRFTSAFKRDYKRYKKKHYPMTKIDKAICLIASEEIDILINQYRLHNLKGEWQGYKELHVDGDTLIIYIDQKGIVTL
TRLGTHDQLF

Download         Length: 273 bp

>T183134 NZ_CP086678:4180149-4180252 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.56 Da        Isoelectric Point: 4.2803

>AT183134 WP_060778044.1 NZ_CP065662:c1515507-1515256 [Aerococcus urinae]
MARINIRVDDDLKEQAKATFEDMGLDLTTAITLFIKYSVNSGELPFKPATKKQIENRQARAEAESDQLKTYDNVDDLLEA
LNE

Download         Length: 252 bp

>AT183134 NZ_CP086678:c4180290-4180019 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109RE66

Antitoxin

Source ID Structure
AlphaFold DB A0A109REE1

References