Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 396750..397249 Replicon chromosome
Accession NZ_CP065662
Organism Aerococcus urinae strain FDAARGOS_911

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0X8FG34
Locus tag I6G68_RS01740 Protein ID WP_060778903.1
Coordinates 396750..397004 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0X8FFP8
Locus tag I6G68_RS01745 Protein ID WP_060778902.1
Coordinates 397004..397249 (-) Length 82 a.a.

Genomic Context

I6G68_RS01725I6G68_RS01730I6G68_RS01735I6G68_RS01760I6G68_RS01770I6G68_RS01720I6G68_RS01740I6G68_RS01745I6G68_RS01750I6G68_RS01755I6G68_RS01765
Location: 393396..394181 (786 bp)
Type: Others
Protein ID: WP_060778906.1
Location: 394250..395197 (948 bp)
Type: Others
Protein ID: WP_060778905.1
Location: 395397..396650 (1254 bp)
Type: Others
Protein ID: WP_060778904.1
Location: 399653..400141 (489 bp)
Type: Others
Protein ID: WP_060778899.1
Location: 401648..401887 (240 bp)
Type: Others
Protein ID: WP_060778897.1
Location: 392224..393162 (939 bp)
Type: Others
Protein ID: WP_060778907.1
Location: 396750..397004 (255 bp)
Type: Toxin
Protein ID: WP_060778903.1
Location: 397004..397249 (246 bp)
Type: Antitoxin
Protein ID: WP_060778902.1
Location: 397387..398124 (738 bp)
Type: Others
Protein ID: WP_060778901.1
Location: 398831..399502 (672 bp)
Type: Others
Protein ID: WP_060778900.1
Location: 400243..401433 (1191 bp)
Type: Others
Protein ID: WP_060778898.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G68_RS01720392224..393162-939WP_060778907.1LysR family transcriptional regulator-
I6G68_RS01725393396..394181+786WP_060778906.1enoyl-CoA hydratase/isomerase family protein-
I6G68_RS01730394250..395197+948WP_060778905.1nitronate monooxygenase family protein-
I6G68_RS01735395397..396650+1254WP_060778904.1CoA transferase-
I6G68_RS01740396750..397004-255WP_060778903.1Txe/YoeB family addiction module toxinToxin
I6G68_RS01745397004..397249-246WP_060778902.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
I6G68_RS01750397387..398124-738WP_060778901.1cyclase family protein-
I6G68_RS01755398831..399502-672WP_060778900.1hypothetical protein-
I6G68_RS01760399653..400141+489WP_060778899.1GNAT family N-acetyltransferase-
I6G68_RS01765400243..401433-1191WP_060778898.1hypothetical protein-
I6G68_RS01770401648..401887+240WP_060778897.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10249.84 Da        Isoelectric Point: 9.9565

>T183132 WP_060778903.1 NZ_CP065662:c397004-396750 [Aerococcus urinae]
MEVHWSKRAVIERDYWKSHDPKIYDKLYKLLRAIKENPYQGLGKPEPLKYDLSGYWSRRLTQQDRLVYRIKSSAIEVLSC
KYHY

Download         Length: 255 bp

>T183132 NZ_CP086678:3998525-3998776 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9532.43 Da        Isoelectric Point: 3.8488

>AT183132 WP_060778902.1 NZ_CP065662:c397249-397004 [Aerococcus urinae]
MEITNYSDFRQNMKKYMDVINEDSVEYTVTSQNGNDVVVMAKSDFDSLMETYHLLSSRANRENLYQAMEELDQGDYEVEE
I

Download         Length: 246 bp

>AT183132 NZ_CP086678:3998773-3999027 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X8FG34

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X8FFP8

References