183132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 396750..397249 Replicon chromosome
Accession NZ_CP065662
Organism Aerococcus urinae strain FDAARGOS_911

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0X8FG34
Locus tag I6G68_RS01740 Protein ID WP_060778903.1
Coordinates 396750..397004 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0X8FFP8
Locus tag I6G68_RS01745 Protein ID WP_060778902.1
Coordinates 397004..397249 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G68_RS01720 392224..393162 - 939 WP_060778907.1 LysR family transcriptional regulator -
I6G68_RS01725 393396..394181 + 786 WP_060778906.1 enoyl-CoA hydratase/isomerase family protein -
I6G68_RS01730 394250..395197 + 948 WP_060778905.1 nitronate monooxygenase family protein -
I6G68_RS01735 395397..396650 + 1254 WP_060778904.1 CoA transferase -
I6G68_RS01740 396750..397004 - 255 WP_060778903.1 Txe/YoeB family addiction module toxin Toxin
I6G68_RS01745 397004..397249 - 246 WP_060778902.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6G68_RS01750 397387..398124 - 738 WP_060778901.1 cyclase family protein -
I6G68_RS01755 398831..399502 - 672 WP_060778900.1 hypothetical protein -
I6G68_RS01760 399653..400141 + 489 WP_060778899.1 GNAT family N-acetyltransferase -
I6G68_RS01765 400243..401433 - 1191 WP_060778898.1 hypothetical protein -
I6G68_RS01770 401648..401887 + 240 WP_060778897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10249.84 Da        Isoelectric Point: 9.9565

>T183132 WP_060778903.1 NZ_CP065662:c397004-396750 [Aerococcus urinae]
MEVHWSKRAVIERDYWKSHDPKIYDKLYKLLRAIKENPYQGLGKPEPLKYDLSGYWSRRLTQQDRLVYRIKSSAIEVLSC
KYHY

Download         Length: 255 bp

>T183132 NZ_CP086678:3998525-3998776 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9532.43 Da        Isoelectric Point: 3.8488

>AT183132 WP_060778902.1 NZ_CP065662:c397249-397004 [Aerococcus urinae]
MEITNYSDFRQNMKKYMDVINEDSVEYTVTSQNGNDVVVMAKSDFDSLMETYHLLSSRANRENLYQAMEELDQGDYEVEE
I

Download         Length: 246 bp

>AT183132 NZ_CP086678:3998773-3999027 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8FG34

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8FFP8

References